NOVEL CHIRAL DERIVATIZING AGENTS FOR H-1 NMR DETERMINATION OF ENANTIOMERIC PURITIES OF CARBOXYLIC ACIDS

摘要

(S)-4-(3-Aminopyrrolidin-l-yl)coumarin (1), (S)-4-(3-aminopiperidin-1-yl)coumarin (4), and (S)-4-(3-aminoazepan-l-yl)coumarin (7), prepared from 4-chlorocoumarin and (S)-pyrrolidin-3-amine, (S)-piperidin-3-amine, and (S)-azepan-3-amine, respectively, were proven to be versatile and reliable H-1 NMR optical purity determination agents for chiral carboxylic acids.