RECENT ADVANCES IN TRANSITION-METAL-CATALYZED SYNTHESIS OF 3-AND/OR 4-ARYL-2(1H)-QUINOLONES

摘要

2(1H)-Quinolone is a privileged nitrogen heterocycle that is found in various bioactive compounds and functional molecules. In particular, derivatives possessing aryl substituents at the 3- and/or 4-positions are significant synthetic targets as they are promising drug leads. This review surveys the synthetic methods for 3- and/or 4-aryl-2(1H)-quinolones that involve transition-metal-catalyzed construction of the 2(1H)-quinolone framework. Transition-metal-catalyzed arylations of 2(1H)-quinolone scaffolds are also surveyed.