ENANTIOSELECTTVE SYNTHESIS OF SPERO (ISOXAZOLE-ISOXAZOLINE) HYBRID LIGANDS

摘要

Enantioselective synthesis of chiral spiro hybrid ligand (R,S)-1 possessing isoxazole and isoxazoline rings as coordination sites was accomplished through a process involving desymmetrized intermediate 5. The key intermediate 5 was readily obtained via chiral Cu-catalyzed mono-acylation of 1,3-diol 3 or enzymatic mono-deacylation of diester 6.