Genome-wide Pleiotropy Between Parkinson Disease and Autoimmune Diseases

Witoelar Aree; Jansen Iris E.; Wang Yunpeng; Desikan Rahul S.; Gibbs J. Raphael; Blauwendraat Cornelis; Thompson Wesley K.; Hernandez Dena G.; Djurovic Srdjan; Schork Andrew J.; Bettella Francesco; Ellinghaus David; Franke Andre; Lie Benedicte A.; McEvoy Linda K.; Karlsen Tomh.; Lesage Suzanne; Morris Huw R.; Brice Alexis; Wood Nicholas W.; Heutink Peter; Hardy John; Singleton Andrew B.; Dale Anders M.; Gasser Thomas; Andreassen Ole A.; Sharma Manu

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Genome-wide Pleiotropy Between Parkinson Disease and Autoimmune Diseases

机译：帕金森病与自身免疫疾病之间的基因组型肺炎

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IMPORTANCE Recent genome-wide association studies (GWAS) and pathway analyses supported long-standing observations of an association between immune-mediated diseases and Parkinson disease (PD). The post-GWAS era provides an opportunity for cross-phenotype analyses between different complex phenotypes.

机译：重要的近期基因组 - 范围协会研究（GWAS）和途径分析支持免疫介导的疾病和帕金森病（PD）之间的关联的长期观察。后GWAS时代为不同复杂表型之间的交叉表型分析提供了机会。

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来源
《JAMA neurology 》 |2017年第7期| 共13页
作者
Witoelar Aree; Jansen Iris E.; Wang Yunpeng; Desikan Rahul S.; Gibbs J. Raphael; Blauwendraat Cornelis; Thompson Wesley K.; Hernandez Dena G.; Djurovic Srdjan; Schork Andrew J.; Bettella Francesco; Ellinghaus David; Franke Andre; Lie Benedicte A.; McEvoy Linda K.; Karlsen Tomh.; Lesage Suzanne; Morris Huw R.; Brice Alexis; Wood Nicholas W.; Heutink Peter; Hardy John; Singleton Andrew B.; Dale Anders M.; Gasser Thomas; Andreassen Ole A.; Sharma Manu;
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作者单位

Univ Oslo KG Jebsen Ctr Psychosis Res Norwegian Ctr Mental Disorders Res NORMENT Oslo Norway;

Vrije Univ VU Univ Med Ctr Dept Clin Genet Amsterdam Netherlands;

Univ Oslo KG Jebsen Ctr Psychosis Res Norwegian Ctr Mental Disorders Res NORMENT Oslo Norway;

Univ Calif San Diego Multimodal Imaging Lab La Jolla CA 92093 USA;

Natl Inst Aging Lab Neurogenet Bethesda MD USA;

German Ctr Neurodegenerat Dis DZNE Tubingen Germany;

Univ Calif San Diego Dept Psychiat La Jolla CA 92093 USA;

Natl Inst Aging Lab Neurogenet Bethesda MD USA;

Univ Oslo KG Jebsen Ctr Psychosis Res Norwegian Ctr Mental Disorders Res NORMENT Oslo Norway;

Univ Calif San Diego Multimodal Imaging Lab La Jolla CA 92093 USA;

Univ Oslo KG Jebsen Ctr Psychosis Res Norwegian Ctr Mental Disorders Res NORMENT Oslo Norway;

Christian Albrechts Univ Kiel Inst Clin Mol Biol Kiel Germany;

Christian Albrechts Univ Kiel Inst Clin Mol Biol Kiel Germany;

Univ Oslo Dept Med Genet Oslo Norway;

Univ Calif San Diego Multimodal Imaging Lab La Jolla CA 92093 USA;

KG Jebsen Inflammat Res Ctr Res Inst Internal Med Oslo Norway;

INSERM Inst Cerveau &

Moelle Epiniere ICM Unite 1127 Paris France;

UCL NHNN Dept Clin Neurosci London England;

INSERM Inst Cerveau &

Moelle Epiniere ICM Unite 1127 Paris France;

UCL Inst Neurol Dept Mol Neurosci London England;

Vrije Univ VU Univ Med Ctr Dept Clin Genet Amsterdam Netherlands;

UCL Rita LilaWeston Inst London England;

Natl Inst Aging Lab Neurogenet Bethesda MD USA;

Univ Calif San Diego Multimodal Imaging Lab La Jolla CA 92093 USA;

German Ctr Neurodegenerat Dis DZNE Tubingen Germany;

Univ Oslo KG Jebsen Ctr Psychosis Res Norwegian Ctr Mental Disorders Res NORMENT Oslo Norway;

Univ Tubingen Hertie Inst Clin Brain Res Dept Neurodegenerat Dis Tubingen Germany;

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正文语种 eng
中图分类神经病学与精神病学 ;
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专利

1. Genome-wide Pleiotropy Between Parkinson Disease and Autoimmune Diseases [J] . Witoelar Aree, Jansen Iris E., Wang Yunpeng, JAMA neurology . 2017 ,第7期

机译：帕金森病与自身免疫疾病之间的基因组型肺炎
2. Alzheimer's disease and Parkinson's disease genome-wide association study top hits and risk of Parkinson's disease in Korean population [J] . GajewskiP.D., ChungS.J., JungY., Neurobiology of Aging: Experimental and Clinical Research . 2013 ,第11期

机译：阿尔茨海默氏病和帕金森氏病全基因组关联研究在韩国人群中帕金森氏症的流行率和风险最高
3. A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases [J] . Han Buhm, Pouget Jennie G., Slowikowski Kamil, Nature Genetics . 2016 ,第7期

机译：一种通过检测自身免疫性和神经精神疾病性疾病隐性亚群驱动的潜在异质性来破译多效性的方法
4. Autoimmune Diseases and Sjoegren's Syndrome: An Autoimmune Exocrinopathy [C] . PHILIP C. FOX, New York Academy of Sciences Conference on Oral-Based Diagnostics . 2007

机译：自身免疫性疾病和Sjogren综合征：一种自身免疫外分疗法
5. Regulatory T cells in CD4+ T cell-mediated autoimmune diseases: Contribution to the disease development and application in the disease prevention. [D] . Zhang, Hong. 2009

机译：CD4 + T细胞介导的自身免疫性疾病中的调节性T细胞：对疾病发展的贡献以及在疾病预防中的应用。
6. Loci Associated with N-Glycosylation of Human Immunoglobulin G Show Pleiotropy with Autoimmune Diseases and Haematological Cancers [O] . Gordan Lauc, Jennifer E. Huffman, Maja Pučić, 2013

机译：与人类免疫球蛋白G的N-糖基化相关的基因座显示多发性与自身免疫性疾病和血液系统癌症
7. A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases [O] . Han, Buhm, Pouget, Jennie G., Slowikowski, Kamil, 2016

机译：一种通过检测由隐藏亚组驱动的潜在异质性来解释多效性的方法应用于自身免疫和神经精神疾病

Genome-wide Pleiotropy Between Parkinson Disease and Autoimmune Diseases

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