Novel Glial Targets and Recurrent Longitudinally Extensive Transverse Myelitis

摘要

A 2014 study~(1) reported that autoimmune aquaporin 4 (AQP4) channelopathy was the most common cause of immune-mediated recurrent longitudinally extensive transverse myelitis (rLETM), with seropositivity in 42 of 47 cases (89%). Autoimmune myelin oligodendrocyte glycoproteinopathy (MOG-opathy) with serum antibodies targeting MOG (MOG-IgG) has recently been reported in AQP4-IgG seronegative longitudinally extensive transverse myelitis (LETM).~(2) Another autoimmune astrocytopathy with glial fibrillary acidic protein (GFAP-IgG) as a biomarker may include myelitis sometimes longitudinally extensive as a component of a meningoencephalomyelitis.~(3) We present additional serological data with regard to 2 novel glial targets (MOG and GFAP) in patients with rLETM.