Suppression of elevated blood NKT cells in recurrent pregnancy failure patients given IV1G correlates with successful pregnancy

摘要

Elevated blood NX cell number and activity has been linked to recurrent spontaneous abortion (RSA) of normal karyotype embryos, but levels in RSA patients overlap the normal fertile patient range. NKT cells have been linked to both occult losses and classical abortions in animal models. Do infertile and RSA patients have elevated NK T cells and is treatment with intravenous immunoglobulin (IVIG) beneficial?