EFFECT OF CISPLATIN ALONE AND IN COMBINATION WITH GAMMA-RADIATION ON THE INITIATION OF DNA SYNTHESIS IN FRIEND LEUKEMIA CELLS

摘要

The effect of the anticancer drug cisplatin (alone and in combination with gamma-radiation) on the initiation of DNA synthesis in Friend leukemia cells was studied. A method for isolation of DNA fractions containing the origins of replication was used. It was found that cisplatin decreased the rate of the initiation of DNA synthesis. The mild gamma-radiation has previously been observed to inhibit the initiation of DNA synthesis. In the present investigation the combination of cisplatin and gamma-radiation showed additive effects without synergism on the initiation of DNA biosynthesis. [References: 10]