Notes on 'Characteristics of gadolinium-DTPA complex: a potential NMR contrast agent'.

摘要

The development of magnetic resonance imaging (MRI) provides a fascinating story, from its tentative early development to theaward of the Nobel Prize, befitting the dominant role this modality serves today in clinical diagnosis. Key to the success of MRI was the development of safe, effective intravenous contrast media, the focus of this invited commentary. The article titled "Characteristics of Gadolinium-DTPA Complex: A Potential NMR Contrast Agent" , published in 1984, served not only as the first description of what was to become the dominant MRI contrast agent for 20 years, but also lay the groundwork for the entire field of gadolinium chelates. It should come as no surprise that this manuscript is the top-cited article published in the American Journal of Roentgenology(AJR) .