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Low Bone Density and Renal Dysfunction following Environmental Cadmium Exposure in China

机译:中国环境镉暴露后低骨密度和肾功能不全

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This paper presents the main findings of a study on health effects of environmental cadmium pollution in China, performed in 1998, i.e. approximately 25 years after the first warnings of such effects were published in Ambio. Forearm bone mineral density (BMD) and renal dysfunction were assessed in population groups exposed to cadmium via rice. Decreased BMD was found in postmenopausal women with elevated urinary cadmium (CdU) or cadmium in blood (CdB) and among men with elevated CdB. Also, clear and statistically significant dose-effect and dose-response relationships were found between CdB or CdU and renal dysfunction (increased excretion of retinol-binding protein). This is the first report of bone effects among Cd-exposed population groups in Asia outside Japan. The report is also of interest since it demonstrates that bone effects, a comparatively severe adverse health effect of Cd, in combination with renal dysfunction, still occurs in environmentally exposed population groups in Asia. Recent reports on bone effects in Cd-exposed population groups in Europe are discussed.
机译:本文介绍了1998年对中国环境镉污染的健康影响进行的一项研究的主要发现,即在Ambio发表有关此类影响的第一个警告后约25年。在通过水稻接触镉的人群中,评估了前臂的骨矿物质密度(BMD)和肾功能不全。在绝经后妇女中尿镉(CdU)升高或血液中镉(CdB)升高的男性和CdB升高的男性发现BMD降低。同样,在CdB或CdU与肾功能不全(视黄醇结合蛋白的排泄增加)之间发现了明显且具有统计学意义的剂量效应和剂量反应关系。这是日本以外亚洲地区镉暴露人群中骨骼影响的第一份报告。该报告也引起了人们的兴趣,因为它表明在亚洲受环境影响的人群中仍会出现骨效应,即镉的相对严重的不利健康效应,并伴有肾功能障碍。讨论了有关欧洲镉暴露人群中骨骼影响的最新报道。

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