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首页> 外文期刊>Helicobacter >Vonoprazan‐ vs proton‐pump inhibitor‐based first‐line 7‐day triple therapy for clarithromycin‐susceptible Helicobacter pyloriHelicobacter pylori : A multicenter, prospective, randomized trial
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Vonoprazan‐ vs proton‐pump inhibitor‐based first‐line 7‐day triple therapy for clarithromycin‐susceptible Helicobacter pyloriHelicobacter pylori : A multicenter, prospective, randomized trial

机译：vonoprazan-vs质子泵抑制剂的一线7日三疗法为克拉霉素 - 易感术幽门螺杆菌幽门螺杆菌幽门螺杆菌：多中心，前瞻性，随机试验

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Abstract <section numbered="no" xml:id="hel12456-sec-0001"> <title type="main">Background > The eradication rate of vonoprazan‐based first‐line triple therapy (combined with clarithromycin and amoxicillin) (V‐ <fc>AC</fc> ) was reported to be 97.6% in patients with clarithromycin ( <fc>CAM</fc> )‐susceptible Helicobacter pylori in a phase <fc>III</fc> study, whereas our real‐world, prospective, multicenter cohort study yielded an eradication rate 90%. </section> <section numbered="no" xml:id="hel12456-sec-0002"> <title type="main">Objective > To validate the eradication rate of V‐ <fc>AC</fc> using <fc>CAM</fc> ‐susceptible testing in a multicenter, prospective, randomized trial. </section> <section numbered="no" xml:id="hel12456-sec-0003"> <title type="main">Methods > We included 147 treatment‐na?ve H.?pylori ‐positive patients [41 with <fc>CAM</fc> ‐resistant infections and 106 with <fc>CAM</fc> ‐susceptible infections]. The <fc>CAM</fc> ‐susceptible group patients were randomized to either the V‐ <fc>AC</fc> group (vonoprazan 20?mg bid, amoxicillin 750?mg bid, and clarithromycin 200 or 400?mg bid) or <fc>PPI</fc> ‐ <fc>AC</fc> group (lansoprazole 30?mg, rabeprazole 10?mg, or esomeprazole 20?mg bid; amoxicillin 750?mg bid; and clarithromycin 200 or 400?mg bid). All <fc>CAM</fc> ‐resistant H.?pylori were eradicated by V‐ </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“main”XML：ID =“Hel12456-Abs-0001”XML：Lang =“en”> <标题类型=“main”>抽象</ title> <sectouned =“no”xml：id = “Hel12456-sec-0001”> <标题类型=“main”>背景</ title> >基于vonoprazan的一线三联治疗的根除率（与克拉霉素和amoxicillin结合）（V- <Fc> AC据报道，Clarithromycin（<FC> Cam </ Fc>）患者的患者为97.6％ - -ceplible 幽门螺杆菌，在A期<FC> III> III>研究中，我们的现实世界，前瞻性，多中心队列研究产生了根除率＆ 90％。 </ p> </ section> <部分编号=“否”XML：ID =“hel12456-sec-0002”> <标题类型=“main”>目标</ title> >以验证v的根除率 - <FC> AC </ FC>在多中心，前瞻性，随机试验中使用<FC> CAM </ FC> -SUSCEPT测试。 </ p> </ section> <secto numbyed =“no”xml：id =“hel12456-sec-0003”> <标题类型=“main”>方法</ title> >我们包括147治疗 - na？ ve H.?丙氏蛋白 - 肌肉[41带<FC> CAM </ FC> -Resistant感染和106型，具有<FC> CAM </ FC> -SUSPLECIBE感染]。 <FC> CAM </ FC> -SUSCOOM组患者被随机化为V- <FC> AC </ FC>组（vonoprazan 20？mg bid，amoxicillin 750？mg BID，以及克拉霉素200或400？mg出价）或<Fc> PPI </ Fc> - <Fc> Ac </ Fc>组（Lansoprazole 30？Mg，Rabeprazole 10？Mg，或eSomeprazole 20？Mg BID; Amoxicillin 750？Mg BID;和克拉霉素200或400？ Mg BID）。所有<fc>凸轮</ fc> -resistant h.?pylori </ i>由V-消除 </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-32409/'>《Helicobacter》</a> <b style="margin: 0 2px;">|</b><span>2018年第2期</span><b style="margin: 0 2px;">|</b><span>共8页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sue Soichiro&option=202" target="_blank" rel="nofollow">Sue Soichiro;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ogushi Marina&option=202" target="_blank" rel="nofollow">Ogushi Marina;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Arima Isao&option=202" target="_blank" rel="nofollow">Arima Isao;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kuwashima Hirofumi&option=202" target="_blank" rel="nofollow">Kuwashima Hirofumi;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Nakao Satoshi&option=202" target="_blank" rel="nofollow">Nakao Satoshi;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Naito Makoto&option=202" target="_blank" rel="nofollow">Naito Makoto;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Komatsu Kazuo&option=202" target="_blank" rel="nofollow">Komatsu Kazuo;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kaneko Hiroaki&option=202" target="_blank" rel="nofollow">Kaneko Hiroaki;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tamura Toshihide&option=202" target="_blank" rel="nofollow">Tamura Toshihide;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sasaki Tomohiko&option=202" target="_blank" rel="nofollow">Sasaki Tomohiko;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kondo Masaaki&option=202" target="_blank" rel="nofollow">Kondo Masaaki;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Shibata Wataru&option=202" target="_blank" rel="nofollow">Shibata Wataru;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Maeda Shin&option=202" target="_blank" rel="nofollow">Maeda Shin;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of GastroenterologyYokohama City University Graduate School of MedicineYokohama Japan;</p> <p>Department of GastroenterologyYokohama Hodogaya Central HospitalYokohama Japan;</p> <p>Department of GastroenterologyYokosuka City HospitalYokosuka Kanagawa Japan;</p> <p>Department of GastroenterologyYokohama Hodogaya Central HospitalYokohama Japan;</p> <p>Department of GastroenterologyYokosuka City HospitalYokosuka Kanagawa Japan;</p> <p>Department of GastroenterologyYokohama Hodogaya Central HospitalYokohama Japan;</p> <p>Department of GastroenterologyYokosuka City HospitalYokosuka Kanagawa Japan;</p> <p>Department of GastroenterologyYokohama City University Graduate School of MedicineYokohama Japan;</p> <p>Department of GastroenterologyYokohama City University Graduate School of MedicineYokohama Japan;</p> <p>Department of GastroenterologyYokohama City University Graduate School of MedicineYokohama Japan;</p> <p>Department of GastroenterologyYokohama City University Graduate School of MedicineYokohama Japan;</p> <p>Advanced Medical Research CenterYokohama City UniversityYokohama Japan;</p> <p>Department of GastroenterologyYokohama City University Graduate School of MedicineYokohama Japan;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/183.html" title="微生物学">微生物学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=7‐day triple therapy&option=203" rel="nofollow">7‐day triple therapy;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=clarithromycin‐susceptible&option=203" rel="nofollow">clarithromycin‐susceptible;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Helicobacter pylori eradication&option=203" rel="nofollow">Helicobacter pylori eradication;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=vonoprazan&option=203" rel="nofollow">vonoprazan;</a> </p> <div class="translation"> 机译：7天三重疗法;克拉霉素易感;幽门螺杆菌根除幽门螺杆菌;vonoprazan; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704025099405.html">Vonoprazan‐ vs 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<span>机译：各种方案在轻度至中度哮喘儿童中维持抗炎治疗方案的有效性：前瞻性多中心随机试验的结果</span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-foreign-pmc_biomed-research-international_thesis/040003394691.html">Efficacy and Safety of Vonoprazan-Based versus Proton Pump Inhibitor-Based Triple Therapy for Helicobacter pylori Eradication: A Meta-Analysis of Randomized Clinical Trials</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Qiu-Ju Lyu&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Qiu-Ju Lyu,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Qiang-Hong Pu&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Qiang-Hong Pu,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Xian-Fei Zhong&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Xian-Fei Zhong,</a> <span>2006</span> </span> </div> <p class="zwjiyix translation" 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href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Schlioma Zaterka&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Schlioma Zaterka,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jaime Natan Eisig&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Jaime Natan Eisig,</a> <span>2001</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：在巴西患有消化性溃疡的患者中，使用质子泵抑制剂，替硝唑和克拉霉素的七天三联疗法根除幽门螺杆菌的因素使用质子泵抑制剂的七天三联疗法，根除幽门螺杆菌的因素与替硝唑和克拉霉素联用在巴西消化性溃疡患者中</span> </p> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-journal-gastroenterology_thesis/0201250721962.html">短程兰索拉唑、克拉霉素和阿莫西林三联疗法根除幽门螺杆菌在东南亚患者中的疗效——5日一日三次疗法和7日一日两次疗法</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . </a> <span> <a href="/journal-cn-15008/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 胃肠病学 </a> </span> <span> . 2000</span><span>,第004期</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-cn_laboratory-medicine-clinic_thesis/0201238197553.html">基因多态性对质子泵抑制剂联合阿莫西林与克拉霉素三联疗法根除幽门螺杆菌效果的影响</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=姜小建&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 姜小建</a> <span> <a href="/journal-cn-12698/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 检验医学与临床 </a> </span> <span> . 2013</span><span>,第021期</span> </span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-remedies-clinics_thesis/0201291846343.html">布拉酵母菌联合以质子泵抑制剂为基础的标准三联疗法对幽门螺杆菌感染患儿幽门螺杆菌根除率及血清细胞因子的影响</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=李文博&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 李文博</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=原瑞芳&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,原瑞芳</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=马丹&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,马丹</a> <span> <a href="/journal-cn-6436/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国药物与临床 </a> </span> <span> . 2021</span><span>,第024期</span> </span> </div> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-journal-gastroenterology_thesis/0201250689300.html">质子泵抑制剂四联疗法作为幽门螺杆菌根除治疗一线方案的临床研究</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=牟方宏&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 牟方宏</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=胡伏莲&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,胡伏莲</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=杨桂彬&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,杨桂彬</a> <span> <a href="/journal-cn-15008/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 胃肠病学 </a> </span> <span> . 2007</span><span>,第009期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-journal-immunology_thesis/0201223348987.html">含幽门螺杆菌特异性抗体牛奶清除幽门螺杆菌效果的临床随机试验</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=赵连梅&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 赵连梅</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=魏思思&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,魏思思</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=武一鹏&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,武一鹏</a> <span> <a href="/journal-cn-5793/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国免疫学杂志 </a> </span> <span> . 2017</span><span>,第002期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-16660_thesis/020221682655.html">含左氧氟沙星的PPI三联疗法一线治疗幽门螺杆菌感染——多中心、随机、平行对照研究</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . </a> <span> <a href="/conference-cn-16660/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中华医学会北京分会第四届全国幽门螺杆菌感染及消化疾病诊治临床论坛 </a> <span> <span> . 2009</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020311707420.html">含低剂量克拉霉素的铋剂四联疗法对幽门螺杆菌根除的疗效评价</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王嘉敏&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 王嘉敏</a> <span> . 2017</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120103530279.html">一种基于人工模拟核酸分子信标的检测幽门螺杆菌克拉霉素耐药位点的方法与试剂盒</a> <b>[P]</b> . <span> 中国专利： CN110819725A </span> <span> . 2020-02-21</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120101124037.html">幽门螺杆菌阴阳性与克拉霉素耐药性同步检测法</a> <b>[P]</b> . <span> 中国专利： CN110184331A </span> <span> . 2019-08-30</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130435290856.html">USE OF NITRIC OXIDE-RELEASING NON STERIODAL ANTIINFLAMMATORY DRUGS, EITHER IN COMBINATION WITH AN ACID SUSCEPTIBLE PROTON PUMP INHIBITOR, OR ALONE, IN THE MANUFACTURE OF MEDICAMENTS FOR THE TREATMENT OF HELICOBACTER PYLORI INFECTIONS</a> <b>[P]</b> . <span> 外国专利： <!-- --> IL146407B </span> <span> . 2007-08-19</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：一氧化氮释放非甾体抗炎药，无论与酸敏感的质子泵抑制剂结合使用，还是单独使用，在制备用于治疗幽门螺杆菌感染的药物中 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130409314739.html">PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF HELICOBACTER PYLORI CONTAINING TWO ANTIBIOTICS AND A PROTON PUMP INHIBITOR.</a> <b>[P]</b> . <span> 外国专利： <!-- --> MX2016003209A </span> <span> . 2017-09-11</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：包含两种抗生素和质子泵抑制剂的治疗幽门螺杆菌的药物组合物。 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