Nongenetically modified        <i >Lactococcus lactisLactococcus lactis        ‐adjuvanted vaccination enhanced innate immunity against        <i >Helicobacter pyloriHelicobacter pylori

Liu Wei; Tan Zhoulin; Liu Hai; Zeng Zhiqin; Luo Shuanghui; Yang Huimin; Zheng Lufeng; Xi Tao; Xing Yingying

摘要

Abstract <section numbered="no" xml:id="hel12426-sec-0001"> <title type="main">Background > Gram‐positive enhancer matrix particles ( <fc>GEM</fc> ) produced by Lactococcus lactis can enhance vaccine‐induced immune response. However, the mechanism under which this adjuvant mounts the efficacy of orally administered vaccines remains unexplored. </section> <section numbered="no" xml:id="hel12426-sec-0002"> <title type="main">Materials and Methods > We used a prophylactic mice model to investigate the mechanism of <fc>GEM</fc> ‐adjuvanted vaccination. Helicobacter pylori urease‐specific antibody response was monitored and detected in murine serum by <fc>ELISA</fc> . Urease‐specific splenic cytokine profile was examined. Gastric inflammatory responses were measured on day 43 or 71 by quantitative real‐time <fc>PCR</fc> , flow cytometry and histology. </section> <section numbered="no" xml:id="hel12426-sec-0003"> <title type="main">Results > We found that <fc>GEM</fc> enhanced the efficiency of oral H.?pylori vaccine by promoting innate immunity. The vaccine <fc>CUE</fc> ‐ <fc>GEM</fc> composed of <fc>GEM</fc> particles and recombinant antigen <fc>CTB</fc> ‐ <fc>UE</fc> provided protection of immunized mice against H.?pylori insult. The protective response was associated with induction of postimmunization gastritis and local Th1/Th17 cell‐medicated immune response. We showe </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“main”XML：ID =“Hel12426-Abs-0001”> <标题类型=“main”>抽象</ title> <sectouned =“no”xml：id =“hel12426-sec-0001” > <标题类型=“main”>背景</标题> >克阳性增强剂矩阵颗粒（<fc> gem </ fc>）由乳酸乳乳乳乳乳杆菌产生，可以增强疫苗诱导的免疫回复。然而，这种佐剂安装在口服给药疫苗的功效的机制仍未探索。 </ p> </段> <部分编号=“否”XML：ID =“Hel12426-SEC-0002”> <标题类型=“main”>材料和方法</标题> >我们使用预防性小鼠探讨<FC> GEM </ FC> -ADJUVANTED疫苗接种机制的模型。幽门螺杆菌（幽门螺杆菌）通过<fc> ELISA </ Fc>在鼠血清中监测和检测尿素特异性抗体反应。检查尿素特异性脾细胞因子谱。通过定量实时<Fc> PCR </ Fc>，流式细胞术和组织学，在第43或71天测量胃炎反应。 </ p> </ section> <secto numbyed =“no”xml：id =“hel12426-sec-0003”> <标题类型=“main”>结果</ title> >我们发现<fc> gem通过促进先天免疫增强口腔 H.?丙氏菌疫苗的效率。疫苗<FC>提示</ FC> - <FC> GEM </ FC>由<FC> GEM </ FC>颗粒组成，重组抗原<FC> CTB </ FC> - <FC> UE </ FC>提供免疫小鼠免疫鼠标的保护。保护响应与解药后胃炎和局部Th1 / Th17细胞 - 药物免疫应答有关。我们展示 </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-32409/'>《Helicobacter》</a> <b style="margin: 0 2px;">|</b><span>2017年第5期</span><b style="margin: 0 2px;">|</b><span>共11页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Liu Wei&option=202" target="_blank" rel="nofollow">Liu Wei;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tan Zhoulin&option=202" target="_blank" rel="nofollow">Tan Zhoulin;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Liu Hai&option=202" target="_blank" rel="nofollow">Liu Hai;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zeng Zhiqin&option=202" target="_blank" rel="nofollow">Zeng Zhiqin;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Luo Shuanghui&option=202" target="_blank" rel="nofollow">Luo Shuanghui;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yang Huimin&option=202" target="_blank" rel="nofollow">Yang Huimin;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zheng Lufeng&option=202" target="_blank" rel="nofollow">Zheng Lufeng;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Xi Tao&option=202" target="_blank" rel="nofollow">Xi Tao;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Xing Yingying&option=202" target="_blank" rel="nofollow">Xing Yingying;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>School of Life Science and TechnologyChina Pharmaceutical UniversityNanjing China;</p> <p>School of Life Science and TechnologyChina Pharmaceutical UniversityNanjing China;</p> <p>School of Life Science and TechnologyChina Pharmaceutical UniversityNanjing China;</p> <p>School of Life Science and TechnologyChina Pharmaceutical UniversityNanjing China;</p> <p>School of Life Science and TechnologyChina Pharmaceutical UniversityNanjing China;</p> <p>School of Life Science and TechnologyChina Pharmaceutical UniversityNanjing China;</p> <p>School of Life Science and TechnologyChina Pharmaceutical UniversityNanjing China;</p> <p>School of Life Science and TechnologyChina Pharmaceutical UniversityNanjing China;</p> <p>School of Life Science and TechnologyChina Pharmaceutical UniversityNanjing China;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/183.html" title="微生物学">微生物学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Helicobacter pylori&option=203" rel="nofollow">Helicobacter pylori;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=innate immunity&option=203" rel="nofollow">innate immunity;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lactococcus lactis&option=203" rel="nofollow">Lactococcus lactis;</a> </p> <div class="translation"> 机译：幽门螺杆菌;先天免疫;乳球菌乳酸; 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2009</span><span>,第004期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-64442_thesis/020222641608.html">杀菌型低聚木糖牛磺酸乳酸菌乳饮料的研制</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=余保宁&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 余保宁</a> <span> <a href="/conference-cn-64442/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 第二届中国奶业大会 </a> <span> <span> . 2011</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020312899118.html">乳酸乳球菌发酵乳链菌肽的研究</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=陈绵龙&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 陈绵龙</a> <span> . 2008</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/061203275944.html">一种发酵产乳酸链球菌素的乳酸乳球菌乳亚种用增效剂及其使用方法</a> <b>[P]</b> . <span> 中国专利： CN105567624B </span> <span> . 2019.04.02</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120108067741.html">一种可发酵产乳酸链球菌素的乳酸乳球菌乳亚种用增效剂及其使用方法</a> <b>[P]</b> . <span> 中国专利： CN105567624A </span> <span> . 2016-05-11</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130450891686.html">Vaccine composition, use of a helicobacter pylori polypeptide flge or a modified form thereof, use of the same, vaccine composition to induce a protective immune response to helicobacter pylori infection, in vitro diagnostic process of helicobacter pylori infection, kit method for detecting helicobacter pylori infection in a mammal including man, and process for eliciting a protective immune response against helicobacter pylori infection in a mammal</a> <b>[P]</b> . <span> 外国专利：  BR9810026A </span> <span> . 2000-09-19</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：疫苗组合物，幽门螺杆菌多肽壁或其修饰形式的用途，其用途，疫苗组合物诱导对幽门螺杆菌感染的保护性免疫应答，幽门螺杆菌感染的体外诊断方法，用于检测幽门螺杆菌感染的试剂盒方法包括人在内的哺乳动物中的表达，以及引起针对幽门螺杆菌感染的保护性免疫应答的方法 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130408747399.html">Lactococcus lactis Th1- Th17- Th2- Composition for Preventing Improving or Treating of Th1-mediated Immune Disease Th17-mediated Immune Disease or Th2-mediated Immune Disease Comprising Extracts from Lactococcus lactis as an Active Ingredients</a> <b>[P]</b> . <span> 外国专利：  KR20170020679A </span> <span> . 2017-02-23</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：乳酸乳球菌Th1-Th17-Th2-预防或改善Th1介导的免疫病的组合物以乳酸乳球菌的提取物为有效成分的Th17介导的免疫病或Th2介导的免疫病 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130408610999.html">Lactococcus lactis Th1- Th17- Th2- Composition for Preventing Improving or Treating of Th1-mediated Immune Disease Th17-mediated Immune Disease or Th2-mediated Immune Disease Comprising Extracts from Lactococcus lactis as an Active Ingredients</a> <b>[P]</b> . <span> 外国专利：  KR101724126B1 </span> <span> . 2017-04-10</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：乳酸乳球菌Th1-Th17-Th2-预防或改善Th1介导的免疫病的组合物以乳酸乳球菌的提取物为有效成分的Th17介导的免疫病或Th2介导的免疫病 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> 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Nongenetically modified Lactococcus lactisLactococcus lactis ‐adjuvanted vaccination enhanced innate immunity against Helicobacter pyloriHelicobacter pylori

摘要