Multimodal Imaging in Malignant Brain Tumors: Enhancing the Preoperative Risk Evaluation for Motor Deficits with a Combined Hybrid MRI-PET and Navigated Transcranial Magnetic Stimulation Approach

摘要

Patients with malignant brain tumors involving the central region underwent a hybrid O-(2-[F-18]fluoroethyl)-L-tyrosine-PET-MR imaging and motor mapping by neuronavigated transcranial magnetic stimulation. The spatial relationship between functional tissue and lesion volumes as depicted by structural and metabolic imaging was analyzed. Tumor infiltration of the M1 region or the corticospinal tract as depicted by FET-PET is highly indicative of motor impairment, better than contrast-enhanced T1WI alone, and is of predictive value for operative-risk evaluation.