A Potential Biomarker in Amyotrophic Lateral Sclerosis: Can Assessment of Brain Iron Deposition with SWI and Corticospinal Tract Degeneration with DTI Help?

Sheelakumari R.; Madhusoodanan M.; Radhakrishnan A.; Ranjith G.; Thomas B.

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A Potential Biomarker in Amyotrophic Lateral Sclerosis: Can Assessment of Brain Iron Deposition with SWI and Corticospinal Tract Degeneration with DTI Help?

机译：肌萎缩性侧索硬化症的潜在生物标志物：使用SWI评估脑铁沉积和使用DTI评估皮质脊髓束变性是否有帮助？

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BACKGROUND AND PURPOSE: Iron-mediated oxidative stress plays a pivotal role in the pathogenesis of amyotrophic lateral sclerosis. This study aimed to assess iron deposition qualitatively and quantitatively by using SWI and microstructural changes in the corticospinal tract by using DTI in patients with amyotrophic lateral sclerosis.

机译：背景与目的：铁介导的氧化应激在肌萎缩性侧索硬化的发病机理中起着关键作用。本研究旨在通过肌萎缩侧索硬化症患者使用SWI定性和定量评估铁沉积，并通过DTI使用DTI对皮质脊髓束微结构变化进行评估。

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《AJNR. American journal of neuroradiology》 |2016年第2期|共7页
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Sheelakumari R.; Madhusoodanan M.; Radhakrishnan A.; Ranjith G.; Thomas B.;
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正文语种 eng
中图分类放射医学;
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1. A Potential Biomarker in Amyotrophic Lateral Sclerosis: Can Assessment of Brain Iron Deposition with SWI and Corticospinal Tract Degeneration with DTI Help? [J] . Sheelakumari R., Madhusoodanan M., Radhakrishnan A., AJNR. American journal of neuroradiology . 2016,第2期

机译：肌萎缩性侧索硬化症的潜在生物标志物：使用SWI评估脑铁沉积和使用DTI评估皮质脊髓束变性是否有帮助？
2. Combined MR spectroscopic imaging and diffusion tensor MRI visualizes corticospinal tract degeneration in amyotrophic lateral sclerosis. [J] . Yin H, Lim CC, Ma L, Journal of neurology . 2004,第10期

机译：结合MR光谱成像和弥散张量MRI可视化肌萎缩性侧索硬化的皮质脊髓束变性。
3. Diffusion tensor imaging for long-term follow-up of corticospinal tract degeneration in amyotrophic lateral sclerosis [J] . S. Jacob, J. Finsterbusch, J. H. Weishaupt, Neuroradiology . 2003,第9期

机译：弥散张量成像对肌萎缩性侧索硬化的皮质脊髓束变性的长期随访
4. Quantification of Corticospinal Tract Atrophy Using Diffusion Tensor Imaging: A Potential Diagnostic Tool in Amyotrophic Lateral Sclerosis [C] . M. H. A. Noureldine, Y. Al Daulei, R. Kikano, IEEE International Multidisciplinary Conference on Engineering Technology . 2018

机译：定量使用弥散张量成像的皮质脊髓束萎缩：肌萎缩性侧索硬化症的潜在诊断工具。
5. Noninvasive Assessment of Neurochemical Biomarkers in Humans with Amyotrophic Lateral Sclerosis: Correlates of Clinical Heterogeneity [D] . Cheong, Ian 2018

机译：肌萎缩性侧索硬化症患者神经化学生物标记物的非侵入性评估：临床异质性的相关性。
6. A Potential Biomarker in Amyotrophic Lateral Sclerosis: Can Assessment of Brain Iron Deposition with SWI and Corticospinal Tract Degeneration with DTI Help? [O] . R. Sheelakumari, M. Madhusoodanan, A. Radhakrishnan, 2016

机译：在肌营养的外侧硬化症中潜在的生物标志物：可以评估与DTI帮助的SWI和皮质脊髓瘤的脑铁沉积吗？
7. Relação entre degeneração do trato córtico-espinhal através de ressonância magnética e escala funcional (ALSFRS) em pacientes com esclerose lateral amiotrófica Correlation between corticospinal tract degeneration through magnetic resonance imaging, and functional scale (ALSFRS) in patients whit amyotrophic lateral sclerosis [O] . Larissa Nery Garcia, Alexandre Vallota da Silva, Henrique Carrete Jr, 2007

机译：肌萎缩侧索硬化患者皮质脊髓束变性与功能量表（aLsFRs）的关系磁共振成像与皮质脊髓束变性和患者功能量表（aLsFRs）的相关性

A Potential Biomarker in Amyotrophic Lateral Sclerosis: Can Assessment of Brain Iron Deposition with SWI and Corticospinal Tract Degeneration with DTI Help?

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