Practical Organocatalysis with (S)- and (R)-5-Pyrrolidin-2-yl-1H-tetrazoles

摘要

The phenomenal renaissance of interest in organocatalysis has been fuelled by the ever-increasing repertoire of organocatalytic reactions of utility to the synthetic organic chemist. Innovative reactions appear weekly in research publications throughout the world, and these developments have spawned a search for newer and more effective catalysts to bring about a myriad of important chemical transformations. As with any evolving scientific (sub)discipline, there exists a need to provide a range of tools to solve particular problems and stimulate the creation of new concepts. The properties, function, and mechanisms of action of the individual organocatalysts are of prime importance for they must tolerate a wide range of chemistries, functional groups, and reaction conditions and, ideally, be of broad synthetic utility.