Discover Unprotected Amino Aldehydes from Professor Yudin

摘要

Professor Andrei Yudin and co-workers have recently described the preparation of bench-stable, unprotected α-amino aldehydes.1 These kinetically amphoteric molecules exist as dimers, and due to the strain of the aziridine ring, resist inter- and intramolecular iminium ion formation. Furthermore, the two functionalities remain orthogonal to each other throughout their transformations, allowing for the reaction of the aldehyde without the requirement of an additional protecting group.