Clinical usefulness of peripheral blood lymphocyte subsets in canine lymphoma

摘要

The classification of canine lymphoid malignancies into groups based on cell of origin (B- or T-cell types) is possible with immunophenotypic analysis. A high frequency of B-cell lymphomas has been described; about 30% of lyrnphomas are of T-cell origin (Teske et al., 1994a; Fournel-Fleury et al., 1997; Grindem et al., 1998). In human medicine the major diagnostic role of blood lymphocyte subset typing is the screening for non-Hodgkin's lymphomas with peripheral blood involvement and their differentation from reactive lymphoproliferative conditions (Thalhammer-Scherrer et al., 2000). The aim of this project is to evaluate the diagnostic efficacy of blood immunophenotyping in dogs with lymphoma in order to detect the blood involvement and the prognostic benefits.