N-Methyl-D-Aspartate Receptor Antagonism has Differential Effects on Alcohol Craving and Drinking in Heavy Drinkers

Krishnan-Sarin Suchitra; OMalley Stephanie S.; Franco Nicholas; Cavallo Dana A.; Morean Meghan; Shi Julia; Pittman Brian; Krystal John H.

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N-Methyl-D-Aspartate Receptor Antagonism has Differential Effects on Alcohol Craving and Drinking in Heavy Drinkers

机译：N-甲基-D-天冬氨酸受体拮抗作用对重度饮酒者的嗜酒和饮酒有不同的影响

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BackgroundThe objective of this study was to determine the effects of the N-methyl-d-aspartate (NMDA) receptor antagonist, memantine (0, 20, 40mg/d), upon alcohol drinking and craving in heavy drinkers with or without a family history (FH) of alcoholism, and to explore the modulatory influence of the presence of impulsivity on these outcomes.

机译：背景本研究的目的是确定N-甲基-d-天冬氨酸（NMDA）受体拮抗剂美金刚（0、20、40mg / d）对有或没有家族史的重度饮酒者饮酒和渴望的影响（FH），并探讨冲动的存在对这些结果的调节作用。

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《Alcoholism: Clinical and experimental research》 |2015年第2期|共8页
作者
Krishnan-Sarin Suchitra; OMalley Stephanie S.; Franco Nicholas; Cavallo Dana A.; Morean Meghan; Shi Julia; Pittman Brian; Krystal John H.;
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正文语种 eng
中图分类中毒及化学性损害;
关键词
Alcohol; Family History; Memantine; Drinking;

机译：酒精;家族史;美金刚;饮酒;

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1. N-Methyl-D-Aspartate Receptor Antagonism has Differential Effects on Alcohol Craving and Drinking in Heavy Drinkers [J] . Krishnan-Sarin Suchitra, OMalley Stephanie S., Franco Nicholas, Alcoholism: Clinical and experimental research . 2015,第2期

机译：N-甲基-D-天冬氨酸受体拮抗作用对重度饮酒者的嗜酒和饮酒有不同的影响
2. Anxiety, Anxiety Sensitivity, and Perceived Stress as Predictors of Recent Drinking, Alcohol Craving, and Social Stress Response in Heavy Drinkers [J] . McCaul Mary E., Hutton Heidi E., Stephens Mary Ann C., Alcoholism: Clinical and experimental research . 2017,第4期

机译：焦虑，焦虑敏感性和感知压力作为最近饮酒，酒精渴望和沉重饮酒者的社会压力反应的预测因素
3. THE ROLE OF CRAVING IN HUMAN ALCOHOL CONSUMPTION IN HEAVY AND LIGHT DRINKERS: THINKING ABOUT DRINKING [J] . Gowin J. L., Sloan M. E., Ramchandani V. A. Alcoholism: Clinical and experimental research . 2017,第Suppla1期

机译：渴望在沉重和轻饮中的人类酒精消费中的作用：思考饮酒
4. A Control System Hypothesis of the N-methyl-D-aspartate Glutamate Receptor's Role in Alcoholism and Alcohol Withdrawal [C] . Mary K. McDonald, James S. Schwaber, Babatunde A. Ogunnaike IFAC World Congress . 2008

机译：N-甲基-D-天冬氨酸谷氨酸受体在酒精中毒和酒精戒断中的控制系统假设
5. Exploring potential pharmacologic treatments for alcoholism: Can the use of drugs selective for the micro-, delta-, and kappa-opioid receptors differentially modulate alcohol drinking?. [D] . Henderson, Angela Nicole. 2012

机译：探索酒精中毒的潜在药物治疗方法：对微，δ和κ阿片类药物受体有选择性的药物使用能否差异调节饮酒？
6. NMDA receptor antagonism has differential effects on alcohol cravingand drinking in heavy drinkers [O] . Suchitra Krishnan-Sarin, Stephanie S. O’Malley, Nicholas Franco, -1

机译：NMDA受体拮抗作用对酒精的渴望有不同的作用和大量饮酒者饮酒
7. Effects of stress and dietary tryptophan enhancement on craving for alcohol in binge and non-binge heavy drinkers [O] . Jelena Nesic, Theodora Duka 2014

机译：压力和膳食色氨酸增强对狂暴和非狂热饮酒者饮酒的影响

N-Methyl-D-Aspartate Receptor Antagonism has Differential Effects on Alcohol Craving and Drinking in Heavy Drinkers

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