In vitro efficacy of a first‐generation valosin‐containing protein inhibitor (CB‐5083) against canine lymphoma

Gareau A.; Rico C.; Boerboom D.; Nadeau M.‐E.

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In vitro efficacy of a first‐generation valosin‐containing protein inhibitor (CB‐5083) against canine lymphoma

机译：含有第一代缬氨酸蛋白抑制剂（CB-5083）对犬淋巴瘤的体外功效

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来源
《Veterinary and Comparative Oncology》 |2018年第3期|共7页
作者
Gareau A.; Rico C.; Boerboom D.; Nadeau M.‐E.;
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作者单位

Faculté de Médecine vétérinaireUniversité de MontrealSt‐Hyacinthe Québec Canada J2C 7C6;

Faculté de Médecine vétérinaireUniversité de MontrealSt‐Hyacinthe Québec Canada J2C 7C6;

Faculté de Médecine vétérinaireUniversité de MontrealSt‐Hyacinthe Québec Canada J2C 7C6;

Faculté de Médecine vétérinaireUniversité de MontrealSt‐Hyacinthe Québec Canada J2C 7C6;

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原文格式 PDF
正文语种 eng
中图分类动物医学（兽医学）;
关键词
canine lymphoma; ER stress; p97; targeted therapy; valosin‐containing protein; VCP;

机译：犬淋巴瘤;ER应激;p97;靶向治疗;含缬氨酸蛋白质;VCP;

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专利

1. In vitro efficacy of a first‐generation valosin‐containing protein inhibitor (CB‐5083) against canine lymphoma [J] . Gareau A., Rico C., Boerboom D., Veterinary and Comparative Oncology . 2018,第3期

机译：含有第一代缬氨酸蛋白抑制剂（CB-5083）对犬淋巴瘤的体外功效
2. Regulation of expression of ABCB1 and LRP genes by mitogen-activated protein kinase/extracellular signal-regulated kinase pathway and its role in generation of side population cells in canine lymphoma cell lines [J] . TomiyasuH., WatanabeM., Goto-KoshinoY., Leukemia and lymphoma . 2013,第6期

机译：丝裂原活化蛋白激酶/细胞外信号调节激酶通路对ABCB1和LRP基因表达的调控及其在犬淋巴瘤细胞系侧群细胞生成中的作用
3. The cloning and expression of matrix metalloproteinase-2 and tissue inhibitor of matrix metalloproteinase 2 in normal canine lymph nodes and in canine lymphoma [J] . Newman R.G., Kitchell B.E., Wallig M.A., Research in Veterinary Science . 2008,第2期

机译：正常犬淋巴结和犬淋巴瘤中基质金属蛋白酶-2和基质金属蛋白酶2组织抑制剂的克隆与表达
4. Biodynamic Imaging of Therapeutic Efficacy for Canine B-cell Lymphoma: Preclinical Trial Results [C] . H. Choi, Z. Li, J. Turek, Dynamics and fluctuations in biomedical photonics XV . 2018

机译：犬B细胞淋巴瘤治疗功效的生物动力学成像：临床前试验结果。
5. Adenovirus-mediated gene delivery of the soluble IL-13 decoy receptor inhibits Hodgkin lymphoma growth in vitro and in vivo. [D] . Trieu, Young. 2003

机译：可溶性IL-13诱饵受体的腺病毒介导的基因递送在体外和体内抑制霍奇金淋巴瘤的生长。
6. Pharmacological targeting of valosin containing protein (VCP) induces DNA damage and selectively kills canine lymphoma cells [O] . Marie-Ève Nadeau, Charlène Rico, Mayra Tsoi, 2015

机译：含缬沙星蛋白（VCP）的药理靶向诱导DNA损伤并选择性杀死犬淋巴瘤细胞
7. A p97/valosin-containing protein inhibitor drug CB-5083 has a potent but reversible off-target effect on phosphodiesterase-6 [O] . Henri Leinonen, Cheng Cheng, Marja Pitkänen, 2021

机译：含P97 /缬氨酸的蛋白质抑制剂药物CB-5083对磷酸二酯酶-6具有效力但可逆的脱靶效果
8. Sorafenib impedes Rift Valley fever virus egress by inhibiting Valosin containing protein function in the cellular secretory pathway. [R] . Mudhasani, R. 2017

机译：索拉非尼通过抑制细胞分泌途径中含有Valosin的蛋白质功能来阻止裂谷热病毒出口。

In vitro efficacy of a first‐generation valosin‐containing protein inhibitor (CB‐5083) against canine lymphoma

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