A Ca2+ Sensor for Exocytosis

摘要

In 1992, Brose et al. showed that the synaptic vesicle (SV) protein p65/synaptotagmin (syt) 1 binds in a mutually dependent manner Ca2+ and anionic phospholipids, prompting the idea that it functions as a Ca2+ sensor for exocytosis. These findings now define two key aspects of excitation-secretion coupling.