Unresponsiveness to meglumine antimoniate in anthroponotic cutaneous leishmaniasis field isolates: analysis of resistance biomarkers by gene expression profiling

Oliaee Razieh Tavakoli; Sharifi Iraj; Afgar Ali; Kareshk Amir Tavakoli; Asadi Arash; Heshmatkhah Amireh; Bamorovat Mehdi; Jafarzadeh Abdollah; Mohammadi Mohammad Ali; Daneshvar Hamid

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Unresponsiveness to meglumine antimoniate in anthroponotic cutaneous leishmaniasis field isolates: analysis of resistance biomarkers by gene expression profiling

机译：对MeGlumine antimoniate在人类皮肤皮肤的锑酸盐阳离子野外分离物中没有反应：基因表达分析分析抗性生物标志物

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BackgroundResistance to antimonials is a fundamental determinant of treatment failure in anthroponotic cutaneous leishmaniasis (ACL). Detection of reliable molecular markers to distinguish unresponsive and responsive parasites is critical for consolidating strategies to monitor drug efficacy.

机译：背景技术对锑脂是人体皮肤嗜利亚病（ACL）治疗失败的基本决定因素。检测可靠的分子标记，以区分非反应和响应寄生虫对于巩固策略来监测药物功效至关重要。

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《Tropical Medicine and International Health: TM and IH》 |2018年第6期|共12页
作者
Oliaee Razieh Tavakoli; Sharifi Iraj; Afgar Ali; Kareshk Amir Tavakoli; Asadi Arash; Heshmatkhah Amireh; Bamorovat Mehdi; Jafarzadeh Abdollah; Mohammadi Mohammad Ali; Daneshvar Hamid;
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作者单位

Kerman Univ Med Sci Dept Med Parasitol &

Mycol Kerman Iran;

Kerman Univ Med Sci Leishmaniasis Res Ctr Kerman Iran;

Kerman Univ Med Sci Res Ctr Hydatid Dis Iran Kerman Iran;

Birjand Univ Med Sci Dept Microbiol Sch Med Birjand Iran;

Kerman Univ Med Sci Dept Med Parasitol &

Mycol Kerman Iran;

Kerman Univ Med Sci Dadbin Hlth Clin Kerman Iran;

Kerman Univ Med Sci Leishmaniasis Res Ctr Kerman Iran;

Kerman Univ Med Sci Dept Immunol Sch Med Kerman Iran;

Kerman Univ Med Sci Res Ctr Hydatid Dis Iran Kerman Iran;

Kerman Univ Med Sci Dept Immunol Sch Med Kerman Iran;

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原文格式 PDF
正文语种 eng
中图分类地方病学;
关键词
antimonial resistance; Leishmania tropica; genetic markers; real-time qPCR; Iran;

机译：抗动抗性;Leishmania Tropica;遗传标记;实时QPCR;伊朗;

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专利

1. Unresponsiveness to meglumine antimoniate in anthroponotic cutaneous leishmaniasis field isolates: analysis of resistance biomarkers by gene expression profiling [J] . Oliaee Razieh Tavakoli, Sharifi Iraj, Afgar Ali, Tropical Medicine and International Health: TM and IH . 2018,第6期

机译：对MeGlumine antimoniate在人类皮肤皮肤的锑酸盐阳离子野外分离物中没有反应：基因表达分析分析抗性生物标志物
2. Host's immune response in unresponsive and responsive patients with anthroponotic cutaneous leishmaniasis treated by meglumine antimoniate: A case-control study of Th1 and Th2 pathways [J] . Bamorovat Mehdi, Sharifi Iraj, Aflatoonian Mohammad Reza, International immunopharmacology . 2019,第期

机译：MeGlumine Antimoniate治疗的人体皮肤无射击患者无响应和响应患者的宿主免疫反应：对TH1和TH2途径的病例对照研究
3. Comparative proteomics study on meglumine antimoniate sensitive and resistant Leishmania tropica isolated from Iranian anthroponotic cutaneous leishmaniasis patients [J] . Eastern Mediterranean Health Journal: Al-Magallat al-Sihhiyyat li-Sarq al-Mutawassit . 2012,第2期

机译：伊朗人为性皮肤利什曼病患者分离的葡甲胺锑酸敏感性和耐药性热带利什曼原虫的比较蛋白质组学研究
4. An across Factor Normalization based SVD Approach to Analysis of Gene Expression Profiles for Uncovering Biomarkers in Ovarian Carcinoma Chemotherapy Responses [C] . Bin Han, Lei zhu, Yanchen, The 2nd International Conference on Bioinformatics and Biomedical Engineering(iCBBE 2008)(第二届生物信息与生物医学工程国际会议）论文集 . 2008

机译：基于跨因子归一化的SVD方法分析基因表达谱以发现卵巢癌化疗反应中的生物标志物
5. Application of gene expression profiling for analyzing plant disease resistance. [D] . Tao, Yi. 2003

机译：基因表达谱分析在植物抗病性分析中的应用。
6. Associated-risk determinants for anthroponotic cutaneous leishmaniasis treated with meglumine antimoniate: A cohort study in Iran [O] . Mohammad Reza Aflatoonian, Iraj Sharifi, Behnaz Aflatoonian, 2019

机译：葡甲胺锑酸盐治疗人为性皮肤利什曼病的相关风险决定因素：伊朗的一项队列研究
7. Successful treatment by adding thalidomide to meglumine antimoniate in a case of refractory anthroponotic mucocutaneous leishmaniasis [O] . Vahid Mashayekhi Goyonlo, Sadegh Vahabi-Amlashi, Faezeh Taghavi 2019

机译：通过将沙利度胺添加到Meglumine antimoniate中的成功治疗在难治性人体霉菌杀菌LeishManiaisis中
8. Comparison of Meglumine Antimoniate and Pentamidine for Peruvian Cutaneous Leishmaniasis [R] . Andersen, E. M. , Cruz-Saldarriaga, M. , Llanos-Cuentas, A. , 2005

机译：葡甲胺锑酸盐与喷他脒对秘鲁皮肤利什曼病的比较

Unresponsiveness to meglumine antimoniate in anthroponotic cutaneous leishmaniasis field isolates: analysis of resistance biomarkers by gene expression profiling

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