Atorvastatin reduces T-cell activation and exhaustion among HIV-infected cART-treated suboptimal immune responders in Uganda: a randomised crossover placebo-controlled trial

Nakanjako Damalie; Ssinabulya Isaac; Nabatanzi Rose; Bayigga Lois; Kiragga Agnes; Joloba Moses; Kaleebu Pontiano; Kambugu Andrew D.; Kamya Moses R.; Sekaly Rafick; Elliott Alison; Mayanja-Kizza Harriet

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Atorvastatin reduces T-cell activation and exhaustion among HIV-infected cART-treated suboptimal immune responders in Uganda: a randomised crossover placebo-controlled trial

机译：阿托伐他汀在乌干达中减少了艾滋病毒感染的服用的服用的服用的次优不免疫响应者的T细胞活化和耗尽：随机交叉安慰剂对照试验

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ObjectiveT-cell activation independently predicts mortality, poor immune recovery and non-AIDS illnesses during combination antiretroviral therapy (cART). Atorvastatin showed anti-immune activation effects among HIV-infected cART-naive individuals. We investigated whether adjunct atorvastatin therapy reduces T-cell activation among cART-treated adults with suboptimal immune recovery.

机译：客体 - 细胞活化独立预测组合抗逆转录病毒治疗（推车）期间的死亡率，免疫恢复和无艾滋病疾病。阿托伐他汀在艾滋病毒感染的购物者野人中显示出抗免疫激活效应。我们调查了辅助阿托伐他汀治疗是否降低了随着次优的免疫恢复的推车治疗的成年人中的T细胞活化。

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《Tropical Medicine and International Health: TM and IH》 |2015年第3期|共11页
作者
Nakanjako Damalie; Ssinabulya Isaac; Nabatanzi Rose; Bayigga Lois; Kiragga Agnes; Joloba Moses; Kaleebu Pontiano; Kambugu Andrew D.; Kamya Moses R.; Sekaly Rafick; Elliott Alison; Mayanja-Kizza Harriet;
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作者单位

Makerere Univ Coll Hlth Sci Dept Med Kampala Uganda;

Makerere Univ Coll Hlth Sci Dept Med Kampala Uganda;

Makerere Univ Coll Hlth Sci Dept Med Microbiol Kampala Uganda;

Makerere Univ Coll Hlth Sci Dept Med Microbiol Kampala Uganda;

Makerere Univ Coll Hlth Sci Infect Dis Inst Kampala Uganda;

Makerere Univ Coll Hlth Sci Dept Med Microbiol Kampala Uganda;

Uganda Virus Res Inst Med Res Council Uganda Entebbe Uganda;

Makerere Univ Coll Hlth Sci Infect Dis Inst Kampala Uganda;

Makerere Univ Coll Hlth Sci Dept Med Kampala Uganda;

Vaccine &

Gene Therapy Inst Florida Port St Lucie FL USA;

Uganda Virus Res Inst Med Res Council Uganda Entebbe Uganda;

Makerere Univ Coll Hlth Sci Dept Med Kampala Uganda;

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原文格式 PDF
正文语种 eng
中图分类地方病学;
关键词
atorvastatin; HIV; AIDS; antiretroviral therapy; adjunct therapy; immune activation; immune recovery; atorvastatine; VIH; SIDA; therapie antiretrovirale; traitement d'appoint; activation immunitaire; reconstitution immunitaire; atorvastatina; VIH; SIDA; terapia antirretroviral; terapia adjunta; activacion inmune; recuperacion inmune;

机译：阿托伐他汀;艾滋病毒;艾滋病;抗逆转录病毒治疗;抗病活化;免疫复苏;艾滋病;艾滋病;抗逆转录病毒治疗;额外的治疗;免疫激活;免疫活化;艾滋病;艾滋病病毒症;Terapia anti retroviral;Trapia andutu;inmune excutu;inmune emputu;inmune emputu;修复了;

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专利

1. Atorvastatin reduces T-cell activation and exhaustion among HIV-infected cART-treated suboptimal immune responders in Uganda: a randomised crossover placebo-controlled trial [J] . Nakanjako Damalie, Ssinabulya Isaac, Nabatanzi Rose, Tropical Medicine and International Health: TM and IH . 2015,第Pta3期

机译：阿托伐他汀减少乌干达HIV感染的cART治疗的次优免疫反应者中的T细胞活化和衰竭：一项随机交叉安慰剂对照试验
2. High T-cell immune activation and immune exhaustion among individuals with suboptimal CD4 recovery after 4 years of antiretroviral therapy in an African cohort [J] . Damalie Nakanjako, Isaac Ssewanyana, Harriet Mayanja-Kizza, BMC Infectious Diseases . 2011,第1期

机译：非洲人群中经过4年抗逆转录病毒治疗后CD4恢复欠佳的个体中的高T细胞免疫激活和免疫力衰竭
3. The immunomodulatory nutritional intervention NR100157 reduced CD4 + T-cell decline and immune activation: A 1-year multicenter randomized controlled double-blind trial in HIV-infected persons not receiving antiretroviral therapy (The BITE Study) [J] . CahnP., RuxrungthamK., GazzardB., Clinical infectious diseases . 2013,第1期

机译：免疫调节营养干预NR100157减少CD4 + T细胞下降和免疫活化：一项为期1年的多中心随机对照双盲试验，用于未接受抗逆转录病毒治疗的HIV感染者（BITE研究）
4. Examining the immune-biology of activated gamma delta T-cells in healthy and simian HIV-infected macaques. [D] . Ali, Zahida. 2009

机译：检查健康和猿猴HIV感染的猕猴中活化的γ-δT细胞的免疫生物学特性。
5. Atorvastatin reduces T-cell activation and exhaustion among HIV-infected cART-treated suboptimal immune responders in Uganda: a randomised crossover placebo-controlled trial [O] . Damalie Nakanjako, Isaac Ssinabulya, Rose Nabatanzi, -1

机译：阿托伐他汀减少乌干达HIV感染的cART治疗的次优免疫反应者中的T细胞活化和衰竭：一项随机交叉安慰剂对照试验
6. Atorvastatin reduces T-cell activation and exhaustion among HIV-infected cART-treated suboptimal immune responders in Uganda: a randomised crossover placebo-controlled trial [O] . Damalie Nakanjako, Isaac Ssinabulya, Rose Nabatanzi, 2015

机译：阿托伐他汀在乌干达中减少了艾滋病毒感染的购物车治疗的次优不免疫响应者的T细胞活化和耗尽：随机交叉安慰剂对照试验

Atorvastatin reduces T-cell activation and exhaustion among HIV-infected cART-treated suboptimal immune responders in Uganda: a randomised crossover placebo-controlled trial

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