Association of PEAR1 rs12041331 polymorphism and pharmacodynamics of ticagrelor in healthy Chinese volunteers

Li Mupeng; Hu Yaodong; Wen Zhipeng; Li Huilan; Hu Xiaolei; Zhang Yanjiao; Zhang Zanling; Xiao Jian; Tang Jie; Chen Xiaoping

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Association of PEAR1 rs12041331 polymorphism and pharmacodynamics of ticagrelor in healthy Chinese volunteers

机译：珍珠1卢比的临界与中国健康中国志愿者的多态性和药效学

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摘要

1. Genetic polymorphisms in platelet endothelial aggregation receptor 1 (PEAR1) were associated with responsiveness to aspirin and P2Y12 receptor antagonists. This study aimed to investigate whether PEAR1 polymorphism is associated with ticagrelor pharmacodynamics in healthy Chinese subjects.

机译：1.血小板内皮聚集受体1（PEAR1）中的遗传多态性与阿司匹林和P2Y12受体拮抗剂的反应性有关。本研究旨在调查PeAR1多态性是否与健康中国受试者的TicagreloR药效学相关。

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来源
《Xenobiotica: the fate of foreign compounds in biological systems》 |2017年第12期|共9页
作者
Li Mupeng; Hu Yaodong; Wen Zhipeng; Li Huilan; Hu Xiaolei; Zhang Yanjiao; Zhang Zanling; Xiao Jian; Tang Jie; Chen Xiaoping;
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作者单位

Cent S Univ Xiangya Hosp Dept Clin Pharmacol Changsha 410008 Hunan Peoples R China;

Changzhi Med Coll Dept Cardiol Heping Hosp Changzhi Shanxi Peoples R China;

Cent S Univ Xiangya Hosp Dept Clin Pharmacol Changsha 410008 Hunan Peoples R China;

Cent S Univ Xiangya Hosp Dept Pharm Changsha Hunan Peoples R China;

Cent S Univ Xiangya Hosp Dept Clin Pharmacol Changsha 410008 Hunan Peoples R China;

Cent S Univ Xiangya Hosp Dept Clin Pharmacol Changsha 410008 Hunan Peoples R China;

Cent S Univ Xiangya Hosp Dept Pharm Changsha Hunan Peoples R China;

Cent S Univ Xiangya Hosp Dept Pharm Changsha Hunan Peoples R China;

Cent S Univ Xiangya Hosp Dept Clin Pharmacol Changsha 410008 Hunan Peoples R China;

Cent S Univ Xiangya Hosp Dept Clin Pharmacol Changsha 410008 Hunan Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类毒物学（毒理学）;
关键词
PEAR1; pharmacokinetics; pharmacodynamics; polymorphisms; ticagrelor;

机译：PEAL1;药代动力学;药效学;多态性;TICAGRELOR;

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专利

1. Association of PEAR1 rs12041331 polymorphism and pharmacodynamics of ticagrelor in healthy Chinese volunteers [J] . Li Mupeng, Hu Yaodong, Wen Zhipeng, Xenobiotica: the fate of foreign compounds in biological systems . 2017,第1a12期

机译：珍珠1卢比的临界与中国健康中国志愿者的多态性和药效学
2. Effect of CYP2C9 and SLCO1B1 polymorphisms on the pharmacokinetics and pharmacodynamics of nateglinide in healthy Chinese male volunteers. [J] . Yu Cheng, Guo Wang, Wei Zhang, European journal of clinical pharmacology . 2013,第3期

机译：CYP2C9和SLCO1B1多态性对那格列奈在中国健康男性志愿者中药代动力学和药效学的影响。
3. Effects of SLCO1B1 polymorphisms on the pharmacokinetics and pharmacodynamics of repaglinide in healthy Chinese volunteers. [J] . He J, Qiu Z, Li N, European journal of clinical pharmacology . 2011,第7期

机译：SLCO1B1多态性对瑞格列奈在健康中国志愿者体内的药代动力学和药效学的影响。
4. Safety, tolerability, pharmacodynamics and pharmacokinetics following single subcutaneous dosesof a teverelix depot formulation in healthy male volunteers [C] . C. MacLean, F. Larsen, R. Piechatzek, Annual meeting exposition of the Controlled Release Society . 2005

机译：在健康男性志愿者中单次皮下注射Teverelix储库制剂后的安全性，耐受性，药效动力学和药代动力学
5. Propafenone pharmacokinetics: GLC-ECD analysis; metabolic induction by phenobarbital in nonsmoking and smoking healthy volunteers; protein binding; pharmacodynamics in patients [D] . Chan, Grace Lap-Yu 1989

机译：普罗帕酮药代动力学：GLC-ECD分析；非吸烟和吸烟健康志愿者的苯巴比妥诱导代谢；蛋白质结合；患者的药效学
6. Effect of CYP3A4∗1G and CYP3A5∗3 Polymorphisms on Pharmacokinetics and Pharmacodynamics of Ticagrelor in Healthy Chinese Subjects [O] . Shuaibing Liu, Xiangfen Shi, Xin Tian, 2017

机译：CYP3A4 * 1G和CYP3A5 * 3基因多态性对替卡格雷的药代动力学和药效学的影响
7. Effect of CYP3A4∗1G and CYP3A5∗3 Polymorphisms on Pharmacokinetics and Pharmacodynamics of Ticagrelor in Healthy Chinese Subjects [O] . Shuaibing Liu, Xiangfen Shi, Xin Tian, 2017

机译：CYp3a4 * 1G和CYp3a5 * 3基因多态性对替卡格雷在中国健康人群中的药代动力学和药效学的影响

Association of PEAR1 rs12041331 polymorphism and pharmacodynamics of ticagrelor in healthy Chinese volunteers

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