Effects of Topical Cova (TM), Tisseel (R) and Adcon (R) Gel Application on the Development of Spinal Peridural Fibrosis: An Experimental Study in Rats

摘要

AIM: Leptomeningeal adhesions and fibrosis in the spinal peridural space are the most common causes of post-laminectomy syndrome. Fibrin sealant agents and membrane barriers are commonly used for hemostasis and sealing purposes in spinal surgery. Peridural fibrosis may be a risk of the usage of these topical agents. In this study, we aimed to compare the effects of Cova (TM), Tisseel (R) and Adcon (R) Gel on the development of spinal peridural fibrosis in the experimental rat model.