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Phase Separation and the Centrosome: A Fait Accompli?

机译:相分离和中心组:既成事实?

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There is currently intense interest in the idea that many membraneless organelles might assemble through phase separation of their constituent molecules into biomolecular 'condensates' that have liquid-like properties. This idea is intuitively appealing, especially for complex organelles such as centrosomes, where a liquid-like structure would allow the many constituent molecules to diffuse and interact with one another efficiently. I discuss here recent studies that either support the concept of a liquid-like centrosome or suggest that centrosomes are assembled upon a more solid, stable scaffold. I suggest that it may be difficult to distinguish between these possibilities. I argue that the concept of biomolecular condensates is an important advance in cell biology, with potentially wide-ranging implications, but it seems premature to conclude that centrosomes, and perhaps other membraneless organelles, are necessarily best described as liquid-like phase-separated condensates.
机译:目前对许多膜细胞器可以通过将它们的组成分子分离成具有液体样特性的生物分子的“缩合物”的相分配的想法感到强烈的兴趣。 该思想直观地吸引,特别是对于诸如Centrosomes的复杂细胞器,其中液体状结构将允许许多组成分子弥漫和彼此有效地相互作用。 我在这里讨论最近的研究表明,支持液体状的中心组的概念,或者表明CentroSomes在更坚固的稳定支架上组装。 我建议,可能难以区分这些可能性。 我认为生物分子缩合物的概念是细胞生物学的重要进步,其潜在的巨大含义,但似乎似乎得出结论是中心,也许是其他膜细胞器,必须最好地描述为液相相分离的缩合物 。

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    《Trends in Cell Biology》 |2019年第8期|共11页
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  • 正文语种 eng
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