Highly Enantioselective Hydroformylation of Alkenes by Rhodium-Diazaphospholane Catalysts

摘要

Rhodium-diazaphospholane complexes catalyze the highly enantioselective hydroformylation of aryl alkenes, vinyl acetates and carboxamides, functionalized allylic substrates, heterocycles, and 1,3-dienes at fast rates and high turnover numbers. The state of the art (> 90% ee) in enantioselective hydroformylation is reviewed and highlighted with applications to organic synthesis.