Aminoacyl Benzotriazolides: Versatile Reagents for the Preparation of Peptides and Their Mimetics and Conjugates

摘要

N-(Protected a-aminoacyl)benzotriazoles are efficient acylating reagents that offer many advantages in the preparation of peptides and their mimetics and conjugates. Advances in tnethodology, made possible by these noyel reagents, have given rise to solution- and solid-phase preparative techniques for generating complex peptides and peptide conjugates, which are useful in the construction of diverse libraries of building blocks for medicinal chemistry.