Application of Caenorhabditis elegans (nematode) and Danio rerio embryo (zebrafish) as model systems to screen for. developmental and reproductive toxicity of Piperazine compounds

摘要

To enable selection of novel chemicals for new processes, there is a recognized need for alternative toxicity screening assays to assess potential risks to man and the environment. For human health hazard assessment these screening assays need to be translational to humans, have high throughput capability, and from an animal welfare perspective be harmonized with the principles of the 3Rs (Reduction, Refinement, Replacement).