Long-term control of viral replication in a group O, human immunodeficiency virus Type 1-infected individual

摘要

Editor: HIV-1 is classically classified into three main groups: M (major), N (non-M, non-0), and O (outlier), with Group P being identified most recently. Evolutionary studies suggest each group represents a distinct cross species transmission of SIVcpz or SIVgor into the human population. HIV-1, Group O has mostly remained endemic to Cameroon and inaccurate diagnosis of Group O infection is a major barrier to treatment in this country. A unique subset of individuals, termed long-term nonprogressors (LTNPs), is able to maintain stable CD4+ T cell counts for greater than 5 years in the absence of antiretroviral therapy. Here we report a patient infected with a Group O HIV-1 isolate who has maintained long-term control of HIV replication in the absence of antiretro viral treatment (ART).