A Population Pharmacokinetic-Pharmacogenetic Model of Lamotrigine in Chinese Children With Epilepsy

Chen Yanan; Xu Shansen; Wang Zhanyou; Zhao Mingming; Wang Huanxin; Lu Tong; Zhao Limei

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A Population Pharmacokinetic-Pharmacogenetic Model of Lamotrigine in Chinese Children With Epilepsy

机译：癫痫患儿乳藻的人口药代动力学 - 药物发生模型

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摘要

Background: The pharmacokinetics of lamotrigine (LTG) is complex and varies significantly among individuals, especially among children. Therefore, this study aimed to establish a population pharmacokinetic (PPK) model of LTG in Chinese children with epilepsy and to comprehensively evaluate the effects of genetic variations in drug-metabolizing enzymes, transporters, and a transcriptional regulator on LTG pharmacokinetics.

机译：背景：乳草嗪（LTG）的药代动力学是复杂的，在个体中有显着变化，特别是儿童。因此，本研究旨在建立癫痫中的中国儿童LTG的人口药代动力学（PPK）模型，全面评估药物代谢酶，转运蛋白和转录调节剂对LTG药代动力学的遗传变异的影响。

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来源
《Therapeutic Drug Monitoring》 |2018年第6期|共8页
作者
Chen Yanan; Xu Shansen; Wang Zhanyou; Zhao Mingming; Wang Huanxin; Lu Tong; Zhao Limei;
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作者单位

China Med Univ Shengjing Hosp Dept Pharm 36 Sanhao St Shenyang 110004 Liaoning Peoples R China;

China Med Univ Shengjing Hosp Dept Pharm 36 Sanhao St Shenyang 110004 Liaoning Peoples R China;

China Med Univ Inst Hlth Sci Key Lab Med Cell Biol Minist Educ Shenyang Liaoning Peoples R;

China Med Univ Shengjing Hosp Dept Pharm 36 Sanhao St Shenyang 110004 Liaoning Peoples R China;

China Med Univ Shengjing Hosp Dept Pharm 36 Sanhao St Shenyang 110004 Liaoning Peoples R China;

Shenyang Pharmaceut Univ Sch Life Sci &

Biopharmaceut Shenyang Liaoning Peoples R China;

China Med Univ Shengjing Hosp Dept Pharm 36 Sanhao St Shenyang 110004 Liaoning Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类生药学（天然药物学）;
关键词
lamotrigine; Chinese children; population pharmacokinetics; genetic polymorphisms;

机译：乳草嗪;中国儿童;人口药代动力学;遗传多态性;

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专利

1. A Population Pharmacokinetic-Pharmacogenetic Model of Lamotrigine in Chinese Children With Epilepsy [J] . Chen Yanan, Xu Shansen, Wang Zhanyou, Therapeutic Drug Monitoring . 2018,第6期

机译：癫痫患儿乳藻的人口药代动力学 - 药物发生模型
2. Population pharmacokinetics of lamotrigine in Chinese children with epilepsy [J] . Da-ke HE, Hai-tao LIU, Li WANG, 中国药理学报：英文版 . 2012,第011期

机译：拉莫三嗪在中国癫痫儿童中的群体药代动力学
3. Population pharmacokinetics of lamotrigine co-administered with valproic acid in Chinese epileptic children using nonlinear mixed effects modeling [J] . Xu Shansen, Liu Limin, Chen Yanan, European journal of clinical pharmacology . 2018,第5期

机译：使用非线性混合效应建模，用非线性混合效应与中国癫痫药中的丙戊酸丙甲酸的人口药代动力学
4. Water intake patterns and sociodemographic determinants of Chinese children: Results from the First National Population-based Survey [C] . Guo Q, Wang B, Cao S, Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology . 2019

机译：中国儿童的饮水方式和社会人口统计学决定因素：第一次全国人口调查结果
5. Pharmacometric analyses of lamotrigine in special populations: Application to pregnant women, younger adult and elderly epilepsy patients. [D] . Polepally, Akshanth Reddy. 2012

机译：拉莫三嗪在特殊人群中的药理学分析：适用于孕妇，年轻成人和老年癫痫患者。
6. Population pharmacokinetics of lamotrigine in Chinese children with epilepsy [O] . Da-ke He, Li Wang, Jiong Qin, 2012

机译：拉莫三嗪在中国癫痫儿童中的群体药代动力学
7. Population pharmacokinetics modeling of oxcarbazepine to characterize drug interactions in Chinese children with epilepsy [O] . Yang Wang, Hua-nian Zhang, Chang-he Niu, 2014

机译：氧化巴西人口的人口药代动力学建模，以癫痫患有癫痫患儿药物相互作用

A Population Pharmacokinetic-Pharmacogenetic Model of Lamotrigine in Chinese Children With Epilepsy

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