Ex Vivo Model to Decipher the Impact of Extracorporeal Membrane Oxygenation on Beta-lactam Degradation Kinetics

Leven Cyril; Fillatre Pierre; Petitcollin Antoine; Verdier Marie-Clemence; Laurent Jerome; Nesseler Nicolas; Launey Yoann; Tattevin Pierre; Bellissant Eric; Flecher Erwan; Lemaitre Florian

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Ex Vivo Model to Decipher the Impact of Extracorporeal Membrane Oxygenation on Beta-lactam Degradation Kinetics

机译：exVivo模型破译体外膜氧合对β-内酰胺降解动力学的影响

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Background: As a consequence of drug sequestration, increase in volume of distribution, or alteration of elimination, extracorporeal membrane oxygenation (ECMO) might lead to inadequate plasma concentrations of vital drugs. The aim of this experimental study was to develop an ex vivo model to better characterize the impact of ECMO procedure on beta-lactam antibiotics pharmacokinetics.

机译：背景：由于药物封存的结果，分布的增加或消除的改变，体外膜氧合（ECMO）可能导致血浆浓度不足的重要药物。该实验研究的目的是开发出EXVIO模型，以更好地表征ECMO程序对β-内酰胺抗生素药代动力学的影响。

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来源
《Therapeutic Drug Monitoring》 |2017年第2期|共5页
作者
Leven Cyril; Fillatre Pierre; Petitcollin Antoine; Verdier Marie-Clemence; Laurent Jerome; Nesseler Nicolas; Launey Yoann; Tattevin Pierre; Bellissant Eric; Flecher Erwan; Lemaitre Florian;
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作者单位

Rennes Univ Hospital Pharmacoepidemiol &

Drug Informat Ctr Dept Clin &

Biol Pharmacol &

Rennes Univ Hosp Dept Infectious Dis Intensive Care Unit Rennes France;

Rennes Univ Hospital Pharmacoepidemiol &

Drug Informat Ctr Dept Clin &

Biol Pharmacol &

Rennes Univ Hospital Pharmacoepidemiol &

Drug Informat Ctr Dept Clin &

Biol Pharmacol &

Rennes Univ Hosp Thorac &

Cardio Vasc Surg Rennes France;

Rennes Univ Hosp Surg Intensive Care Unit Rennes France;

Rennes Univ Hosp Surg Intensive Care Unit Rennes France;

INSERM Clin Invest Ctr 1414 CIC P Rennes France;

Rennes Univ Hospital Pharmacoepidemiol &

Drug Informat Ctr Dept Clin &

Biol Pharmacol &

INSERM Clin Invest Ctr 1414 CIC P Rennes France;

Rennes Univ Hospital Pharmacoepidemiol &

Drug Informat Ctr Dept Clin &

Biol Pharmacol &

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原文格式 PDF
正文语种 eng
中图分类生药学（天然药物学）;
关键词
extracorporeal membrane oxygenation; pharmacokinetics; beta-lactam; antibiotics;

机译：体外膜氧合;药代动力学;β-内酰胺;抗生素;

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专利

1. Ex Vivo Model to Decipher the Impact of Extracorporeal Membrane Oxygenation on Beta-lactam Degradation Kinetics [J] . Leven Cyril, Fillatre Pierre, Petitcollin Antoine, Therapeutic Drug Monitoring . 2017,第2期

机译：exVivo模型破译体外膜氧合对β-内酰胺降解动力学的影响
2. Influence of extracorporeal membrane oxygenation on the pharmacokinetics of ceftolozane/tazobactam: an ex vivo and in vivo study [J] . Camille Mané, Clément Delmas, Jean Porterie, Journal of Translational Medicine . 2020,第1期

机译：体外膜氧合对辣椒/唑唑胺的药代动力学的影响：EXVIVO和体内研究
3. Impact of ex-vivo extracorporeal membrane oxygenation circuitry on daptomycin [J] . Cies Jeffrey J., Moore Wayne S. II, Giliam Nadji, Perfusion . 2018,第8期

机译：在达达胺霉素上的ex-体内体外膜氧合电路的影响
4. In Vivo Validation of an Automatic Controlled Extracorporeal Membrane Oxygenator [C] . T. Wartzek, M. Walter, T. Schmitz-Rode, World congress on medical physics and biomedical engineering;International congress of the IUPESM . 2011

机译：自动控制的体外膜氧合器的体内验证
5. Development of computational mass and momentum transfer models for extracorporeal hollow fiber membrane oxygenators. [D] . Gage, Kenneth Leslie. 2007

机译：体外中空纤维膜充氧器的计算质量和动量传递模型的开发。
6. Influence of extracorporeal membrane oxygenation on the pharmacokinetics of ceftolozane/tazobactam: an ex vivo and in vivo study [O] . Camille Mané, Clément Delmas, Jean Porterie, 2020

机译：体外膜氧合对头孢洛赞/他唑巴坦药代动力学的影响：体外和体内研究
7. Models for plasma kinetics during simultaneous therapeutic plasma exchange and extracorporeal membrane oxygenation [O] . Charles Puelz, Zach Danial, Jay S Raval, 2021

机译：同时治疗等离子体交换和体外膜氧合期间等离子体动力学模型

Ex Vivo Model to Decipher the Impact of Extracorporeal Membrane Oxygenation on Beta-lactam Degradation Kinetics

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