Quantification of Thiopurine Nucleotides in Erythrocytes and Clinical Application to Pediatric Acute Lymphoblastic Leukemia

Moon Soo Young; Lim Ji-Hyun; Kim Eun-Hee; Nam Youngwon; Yu Kyung-Sang; Hong Kyung Taek; Choi Jung Yoon; Hong Che Ry; Kim Hyery; Kang Hyoung Jin; Shin Hee Young; Lee Kyunghoon; Song Junghan; Lee Soo-Youn; Song Sang Hoon

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Quantification of Thiopurine Nucleotides in Erythrocytes and Clinical Application to Pediatric Acute Lymphoblastic Leukemia

机译：红细胞中硫氨酸核苷酸的定量与临床应用对小儿急性淋巴细胞白血病

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Background: Concentrations of 6-thioguanine (6TG) nucleotides and 6-methylmercaptopurine (6MMP) nucleotides in RBCs were measured using liquid chromatography-tandem mass spectrometry (LC-MS/MS). This assay was validated for clinical use and was applied to blood samples from patients taking mercaptopurine (6MP).

机译：背景技术使用液相色谱 - 串联质谱法（LC-MS / MS）测量RBC中6-硫核苷酸（6Tg）核苷酸和6-甲基汞孔（6mMP）核苷酸的浓度。该测定验证用于临床用途，并应用于服用巯基嘌呤（6MP）的患者的血液样本。

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来源
《Therapeutic Drug Monitoring》 |2019年第1期|共11页
作者
Moon Soo Young; Lim Ji-Hyun; Kim Eun-Hee; Nam Youngwon; Yu Kyung-Sang; Hong Kyung Taek; Choi Jung Yoon; Hong Che Ry; Kim Hyery; Kang Hyoung Jin; Shin Hee Young; Lee Kyunghoon; Song Junghan; Lee Soo-Youn; Song Sang Hoon;
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作者单位

Seoul Natl Univ Coll Med Dept Lab Med Seoul South Korea;

Seoul Natl Univ Coll Med Inst Biomed Res Seoul South Korea;

Seoul Natl Univ Coll Med Inst Biomed Res Seoul South Korea;

Seoul Natl Univ Coll Med Dept Lab Med Seoul South Korea;

Seoul Natl Univ Coll Med Dept Clin Pharmacol &

Therapeut Seoul South Korea;

Seoul Natl Univ Coll Med Dept Pediat Seoul South Korea;

Seoul Natl Univ Coll Med Dept Pediat Seoul South Korea;

Seoul Natl Univ Coll Med Dept Pediat Seoul South Korea;

Seoul Natl Univ Coll Med Dept Pediat Seoul South Korea;

Seoul Natl Univ Coll Med Dept Pediat Seoul South Korea;

Seoul Natl Univ Coll Med Dept Pediat Seoul South Korea;

Seoul Natl Univ Bundang Hosp Dept Lab Med Seongnam South Korea;

Seoul Natl Univ Bundang Hosp Dept Lab Med Seongnam South Korea;

Sungkyunkwan Univ Sch Med Samsung Med Ctr Dept Lab Med &

Genet Seoul South Korea;

Seoul Natl Univ Coll Med Dept Lab Med Seoul South Korea;

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原文格式 PDF
正文语种 eng
中图分类生药学（天然药物学）;
关键词
RBC; 6-thioguanine (6TG); 6-methylmercaptopurine (6MMP); LC-MS/MS; pediatric ALL;

机译：RBC;6-Thioguanine（6tg）;6-甲基汞孔（6mmp）;LC-MS / MS;小儿;

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专利

1. Quantification of Thiopurine Nucleotides in Erythrocytes and Clinical Application to Pediatric Acute Lymphoblastic Leukemia [J] . Moon Soo Young, Lim Ji-Hyun, Kim Eun-Hee, Therapeutic Drug Monitoring . 2019,第1期

机译：红细胞中硫氨酸核苷酸的定量与临床应用对小儿急性淋巴细胞白血病
2. Incorporation of 6-thioguanine nucleotides into DNA during maintenance therapy of childhood acute lymphoblastic leukemia-the influence of thiopurine methyltransferase genotypes [J] . EbbesenM.S., NerstingJ., JacobsenJ.H., The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology . 2013,第6期

机译：在儿童急性淋巴细胞白血病的维持治疗中将6-硫鸟嘌呤核苷酸掺入DNA-硫嘌呤甲基转移酶基因型的影响
3. Clinical implication of thiopurine methyltransferase polymorphism in children with acute lymphoblastic leukemia: A preliminary Egyptian study [J] . Farida H El-Rashedy, Seham Mohammed Ragab, Ashraf A Dawood, Indian Journal of Medical and Paediatric Oncology . 2015,第4期

机译：硫代嘌呤甲基转移酶基因多态性在急性淋巴细胞白血病儿童中的临床意义：一项埃及初步研究
4. Outcome in acute lymphoblastic leukemia:Influence of thiopurine methyltransferasegenetic polymorphisms [C] . E. Oliveira, S. Alves deg, S. Quental, International Society for Forensic Genetics . 2006

机译：急性淋巴细胞白血病的结果：硫氨酸甲基转移酶生物态的影响
5. Pharmacogenetics of thiopurine- and etoposide-induced malignancies in childhood acute lymphoblastic leukemia. [D] . Edick, Mathew James. 2003

机译：儿童急性淋巴细胞白血病中硫嘌呤和依托泊苷诱导的恶性肿瘤的药理遗传学。
6. Quantification of Thiopurine Nucleotides in Erythrocytes and Clinical Application to Pediatric Acute Lymphoblastic Leukemia [O] . Soo Young Moon, Ji-Hyun Lim, Eun-Hee Kim, -1

机译：红细胞中硫嘌呤核苷酸的定量分析及其在小儿急性淋巴细胞白血病中的临床应用
7. Quantification of Thiopurine Nucleotides in Erythrocytes and Clinical Application to Pediatric Acute Lymphoblastic Leukemia [O] . Soo Young Moon, Ji-Hyun Lim, Eun-Hee Kim, 2019

机译：红细胞硫氨酰核苷酸的定量与临床应用对小儿急性淋巴细胞白血病

Quantification of Thiopurine Nucleotides in Erythrocytes and Clinical Application to Pediatric Acute Lymphoblastic Leukemia

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