Clinical Applications of Physiologically Based Pharmacokinetic Modeling: Perspectives on the Advantages and Challenges

Emoto Chie; McPhail Brooks T.; Fukuda Tsuyoshi

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Clinical Applications of Physiologically Based Pharmacokinetic Modeling: Perspectives on the Advantages and Challenges

机译：生理基于药代动力学建模的临床应用：看优势与挑战的观点

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来源
《Therapeutic Drug Monitoring》 |2020年第1期|共2页
作者
Emoto Chie; McPhail Brooks T.; Fukuda Tsuyoshi;
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作者单位

Cincinnati Childrens Hosp Med Ctr Div Clin Pharmacol Cincinnati OH 45229 USA;

Univ South Carolina Sch Med Greenville Dept Biomed Sci Greenville SC USA;

Cincinnati Childrens Hosp Med Ctr Div Clin Pharmacol Cincinnati OH 45229 USA;

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原文格式 PDF
正文语种 eng
中图分类生药学（天然药物学）;
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1. Clinical Applications of Physiologically Based Pharmacokinetic Modeling: Perspectives on the Advantages and Challenges [J] . Emoto Chie, McPhail Brooks T., Fukuda Tsuyoshi Therapeutic Drug Monitoring . 2020,第1期

机译：生理基于药代动力学建模的临床应用：看优势与挑战的观点
2. Application of physiologically based pharmacokinetic modeling to understanding the clinical pharmacokinetics of UK-369,003. [J] . Watson KJ, Davis J, Jones HM Drug Metabolism and Disposition: The Biological Fate of Chemicals . 2011,第7期

机译：基于生理学的药代动力学建模在理解UK-369,003的临床药代动力学中的应用。
3. Delivery advantage to the unilateral kidney by direct drug application to the kidney surface in rats and pharmacokinetic verification based on a physiological model. [J] . Nishida K, Kamenosono M, Kuma A, Journal of drug targeting . 2005,第4期

机译：通过直接向大鼠肾脏表面施用药物和基于生理模型的药代动力学验证，可以将药物递送至单侧肾脏。
4. A new Perspective on Closed-Loop Glucose Control using a Physiology-Based Pharmacokinetic/Pharmacodynamic Model Kernel [C] . Stephan Schaller, Stefan Willmann, Lukas Schaupp, IFAC Symposium on Biological and Medical Systems . 2012

机译：基于生理学的药代动力学/药效学模型核的闭环血糖控制一种新的视角
5. Physiologically-Based Pharmacokinetic Modelling: Pre-Clinical and Clinical Pharmacokinetic Studies [D] . Rodrigues, Clare Louise. 2008

机译：基于生理的药代动力学模型：临床前和临床药代动力学研究
6. Development of a physiologically based pharmacokinetic model for mefloquine and its application alongside a clinical effectiveness model to select an optimal dose for prevention of malaria in young Caucasian children [O] . Trevor N. Johnson, Yumi Cleary, Neil Parrott, 2019

机译：甲氟喹基于生理学的药代动力学模型的开发及其在临床有效性模型中的应用以选择最佳剂量预防疟疾在高加索儿童中
7. Delivery advantage to the unilateral kidney by direct drug application to the kidney surface in rats and pharmacokinetic verification based on a physiological model [O] . Nishida, Koyo, Kamenosono, Manabu, Kuma, Akiko, 2005

机译：通过直接药物施用到大鼠肾脏表面和基于生理模型的药代动力学验证来递送单侧肾脏的优势
8. Applications of Sensitivity Analysis to a Physiologically Based Pharmacokinetic Model for Carbon Tetrachloride in Rats [R] . Evans, M. V., Crank, W. D., Yang, H. M., 1994

机译：灵敏度分析在大鼠四氯化碳生理药代动力学模型中的应用

Clinical Applications of Physiologically Based Pharmacokinetic Modeling: Perspectives on the Advantages and Challenges

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