Diagnostic contribution of individual components of adrenal function tests to diagnose canine hyperadrenocorticism

摘要

There is limited information regarding the value of constitutive components of the ACTH stimulation test (ACTHST) and low-dose dexamethasone suppression test (LDDST) including serum baseline cortisol (BC), difference between post-ACTH stimulation cortisol (PC) and BC (Delta ACTHC), cortisol concentration 4 h after dexamethasone administration (4HC), difference between 4HC and BC (Delta 4C), and the difference between cortisol concentration 8 h after dexamethasone administration and 4HC (Delta 8C). Therefore, the objective of this study was to determine if these components can predict hyperadrenocorticism, pituitary-dependent hyperadrenocorticism (PDH), or functional adrenocortical tumor (FAT) in dogs. Cortisol concentrations were normalized, as fold change (FC), to the PC reference interval upper limit.