Treatment of Congenital Toxoplasmosis Safety of the Sulfadoxine-Pyrimethamine Combination in Children Based on a Method of Causality Assessment

摘要

Background: The treatment of newborns and infants with congenital toxoplasmosis is standard practice. Some observational studies have examined safety in newborns, but most of these failed to provide sufficient details for a provisional assessment of causality. The aim of this study was to evaluate the clinical and biological adverse effects of the combination of sulfadoxine-pyrimethamine.