Commentary: Significantly less anti-gc antibody detectable in sera collected after varicella vaccination than after the disease varicella

摘要

Physicians have measured antibody titers after varicella for the past 80 years.1"3 More recent studies have measured antibody responses to individual varicella-zoster virus (VZV) protein antigens after varicella.4-5 Some studies have measured VZV antibody responses to VZV protein antigens after varicella vaccination.6"9 But no study until now has measured the antibody responses to VZV glycoprotein C (gC) antigen after both varicella and varicella vaccination. The VZV serology study included 57 vaccinees in Germany. Approximately 90% had received Varilrix (Glaxo SmithKline Vaccines, Rixensart, Belgium) and 10% Varivax (Merck, Whitehouse Station, NJ) vaccine (personal communication from Dr. Jenke, MD, July 11,2012). The result in the article by Jenke et al'?is both unexpected and potentially important for our understanding of the effectiveness of varicella vaccination. The investigators discovered that the VZV anti-gC titer after varicella vaccination was significantly lower than after wild-type varicella (P = 0.006).