Phase I/II trial of combined kyphoplasty and intraoperative radiotherapy in spinal metastases

Bludau Frederic; Welzel Grit; Reis Tina; Schneider Frank; Sperk Elena; Neumaier Christian; Ehmann Michael; Clausen Sven; Obertacke Udo; Wenz Frederik; Giordano Frank A.

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Phase I/II trial of combined kyphoplasty and intraoperative radiotherapy in spinal metastases

机译：脊髓转移术中脑膜膜组合和术中放射治疗的I / II试验

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BACKGROUND CONTEXT: Spinal metastases occur in 30%-50% of patients with systemic cancer. The primary goals of palliation are pain control and prevention of local recurrence.

机译：背景技术：脊柱转移发生在30％-50％的全身癌症患者中。 Palliation的主要目标是疼痛控制和预防局部复发。

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来源
《The spine journal: official journal of the North American Spine Society》 |2018年第5期|共6页
作者
Bludau Frederic; Welzel Grit; Reis Tina; Schneider Frank; Sperk Elena; Neumaier Christian; Ehmann Michael; Clausen Sven; Obertacke Udo; Wenz Frederik; Giordano Frank A.;
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作者单位

Heidelberg Univ Med Fac Mannheim Univ Med Ctr Mannheim Dept Orthoped &

Trauma Surg Theodor;

Heidelberg Univ Med Fac Mannheim Univ Med Ctr Mannheim Dept Radiat Oncol Theodor Kutzer Ufer 1;

Heidelberg Univ Med Fac Mannheim Univ Med Ctr Mannheim Dept Radiat Oncol Theodor Kutzer Ufer 1;

Heidelberg Univ Med Fac Mannheim Univ Med Ctr Mannheim Dept Radiat Oncol Theodor Kutzer Ufer 1;

Heidelberg Univ Med Fac Mannheim Univ Med Ctr Mannheim Dept Radiat Oncol Theodor Kutzer Ufer 1;

Heidelberg Univ Med Fac Mannheim Univ Med Ctr Mannheim Dept Radiat Oncol Theodor Kutzer Ufer 1;

Heidelberg Univ Med Fac Mannheim Univ Med Ctr Mannheim Dept Radiat Oncol Theodor Kutzer Ufer 1;

Heidelberg Univ Med Fac Mannheim Univ Med Ctr Mannheim Dept Radiat Oncol Theodor Kutzer Ufer 1;

Heidelberg Univ Med Fac Mannheim Univ Med Ctr Mannheim Dept Orthoped &

Trauma Surg Theodor;

Heidelberg Univ Med Fac Mannheim Univ Med Ctr Mannheim Dept Radiat Oncol Theodor Kutzer Ufer 1;

Heidelberg Univ Med Fac Mannheim Univ Med Ctr Mannheim Dept Radiat Oncol Theodor Kutzer Ufer 1;

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原文格式 PDF
正文语种 eng
中图分类骨科学（运动系疾病、矫形外科学）;
关键词
Cement augmentation; Intraoperative radiotherapy; IORT; Kyphoplasty; Metastatic spine tumor; Vertebral metastases;

机译：水泥增强;术中放疗;IORT;脑膜成形术;转移性脊柱肿瘤;椎体转移;

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专利

1. Phase I/II trial of combined kyphoplasty and intraoperative radiotherapy in spinal metastases [J] . Bludau Frederic, Welzel Grit, Reis Tina, The spine journal: official journal of the North American Spine Society . 2018,第5期

机译：脊髓转移术中脑膜膜组合和术中放射治疗的I / II试验
2. Intraoperative Radiotherapy during Kyphoplasty (Kypho IORT) in Patients with Vertebral Metastases: Phase II Dose Escalation Study and Update the clinical Data from the Pilot Phase [J] . Reis T., Bludau F., Welzel G., Strahlentherapie und Onkologie . 2015,第Suppla1期

机译：椎骨转移患者在椎体成形术（Kypho IORT）期间进行术中放疗：II期剂量递增研究并从试验期更新临床数据
3. Development of a novel method for intraoperative radiotherapy during kyphoplasty for spinal metastases (Kypho-IORT). [J] . Schneider F, Greineck F, Clausen S, International Journal of Radiation Oncology, Biology, Physics . 2011,第4期

机译：脊柱后凸成形术（Kypho-IORT）术中放疗的新方法的开发。
4. Statistical Methods for Combining Clinical Trial Phases II And III [C] . Nigel Stallard, Susan Todd International Conference on Statistics in Health Sciences . 2007

机译：结合临床试验阶段II和III的统计方法
5. Phase II double-blinded randomized controlled clinical trial of chondroitinase ABC by intraspinal injection for treatment of severe chronic spinal cord injury in 60 pet dogs. [D] . Hu, Hilary. 2016

机译：脊髓内注射软骨素酶ABC的II期双盲随机对照临床试验，用于治疗60只宠物狗的严重慢性脊髓损伤。
6. Combined kyphoplasty and intraoperative radiotherapy (Kypho-IORT) versus external beam radiotherapy (EBRT) for painful vertebral metastases - a randomized phase III study [O] . Frederic Bludau, Grit Welzel, Tina Reis, 2019

机译：后凸成形术和术中放疗（Kypho-IORT）与外束放疗（EBRT）的联合治疗疼痛性椎骨转移-一项随机的III期研究
7. Combined kyphoplasty and intraoperative radiotherapy (Kypho-IORT) versus external beam radiotherapy (EBRT) for painful vertebral metastases - a randomized phase III study [O] . Frederic Bludau, Grit Welzel, Tina Reis, 2019

机译：脑膜术和术中放射疗法（Kypho-Iort）与疼痛椎体转移的外梁放射疗法（EBRT） - 一种随机期III研究
8. Tritherapy (Spinalon)-Elicited Spinal Locomotor Network Activation: Phase I-IIa Clinical Trial in Spinal Cord-Injured Patients. [R] . Guertin, P., Vaillancourt, M. 2013

机译：Tritherapy（spinalon） - 激活脊髓运动网络激活：脊髓损伤患者的I-IIa期临床试验。

Phase I/II trial of combined kyphoplasty and intraoperative radiotherapy in spinal metastases

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