Effects of alendronate on lumbar intervertebral disc degeneration with bone loss in ovariectomized rats

Song Huiping; Luo Yang; Wang Wenya; Li Shuyang; Yang Kai; Dai Muwei; Shen Yong; Zhang Yingze; Zhang Liu

首页> 外文期刊>The spine journal: official journal of the North American Spine Society >Effects of alendronate on lumbar intervertebral disc degeneration with bone loss in ovariectomized rats

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Effects of alendronate on lumbar intervertebral disc degeneration with bone loss in ovariectomized rats

机译：Alengetronate对卵巢切除大鼠骨质缺失性腰椎间盘变性的影响

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BACKGROUND CONTEXT: Osteoporosis adversely affects disc degeneration cascades, and prophylactic alendronate (ALN) helps delay intervertebral disc degeneration (IDD) in ovariectomized (OVX) rats. However, there remains no information regarding whether ALN affects IDD with bone loss.

机译：背景技术：骨质疏松症对盘变性级联产生不利影响，并且预防性阿仑膦酸盐（ALN）有助于延迟卵巢切除（OVX）大鼠的椎间盘退化（IDD）。但是，仍然没有关于ALN是否影响IDD的信息，仍然没有骨质损失。

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来源
《The spine journal: official journal of the North American Spine Society》 |2017年第7期|共9页
作者
Song Huiping; Luo Yang; Wang Wenya; Li Shuyang; Yang Kai; Dai Muwei; Shen Yong; Zhang Yingze; Zhang Liu;
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作者单位

North China Univ Sci &

Technol Affiliated Hosp Dept Orthopaed Surg 73 Jianshe Rd Tangshan;

Hebei Med Univ Hosp 3 Dept Orthopaed Surg 139 Ziqiang Rd Shijiazhuang 050051 Hebei Peoples R;

North China Univ Sci &

Technol Sch Basic Med Sci Dept Pathol 73 Jianshe Rd Tangshan 063000;

North China Univ Sci &

Technol Affiliated Hosp Dept Orthopaed Surg 73 Jianshe Rd Tangshan;

North China Univ Sci &

Technol Affiliated Hosp Dept Orthopaed Surg 73 Jianshe Rd Tangshan;

Hebei Med Univ Hosp 3 Dept Orthopaed Surg 139 Ziqiang Rd Shijiazhuang 050051 Hebei Peoples R;

Hebei Med Univ Hosp 3 Dept Orthopaed Surg 139 Ziqiang Rd Shijiazhuang 050051 Hebei Peoples R;

Hebei Med Univ Hosp 3 Dept Orthopaed Surg 139 Ziqiang Rd Shijiazhuang 050051 Hebei Peoples R;

North China Univ Sci &

Technol Affiliated Hosp Dept Orthopaed Surg 73 Jianshe Rd Tangshan;

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原文格式 PDF
正文语种 eng
中图分类骨科学（运动系疾病、矫形外科学）;
关键词
Alendronate; Lumbar disc degeneration; Osteoporosis; Ovariectomy; Postmenopausal; Rat;

机译：Alendronate;腰椎间盘退化;骨质疏松症;卵巢切除术;绝经后术;老鼠;

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专利

1. Effects of alendronate on lumbar intervertebral disc degeneration with bone loss in ovariectomized rats [J] . Song Huiping, Luo Yang, Wang Wenya, The spine journal: official journal of the North American Spine Society . 2017,第7期

机译：Alengetronate对卵巢切除大鼠骨质缺失性腰椎间盘变性的影响
2. Alendronate Prevents Intervertebral Disc Degeneration Adjacent to a Lumbar Fusion in Ovariectomized Rats [J] . Zhou Zhuang, Tian Fa-Ming, Wang Peng, Spine . 2015,第20期

机译：阿仑膦酸钠可防止去卵巢大鼠腰椎融合附近椎间盘退变
3. Alendronate retards the progression of lumbar intervertebral disc degeneration in ovariectomized rats [J] . LuoY., ZhangL., WangW.-Y., Bone . 2013,第2期

机译：阿仑膦酸盐延缓去卵巢大鼠腰椎间盘退变的进展
4. A comparative study on spatio-temporal parameters of walking gait of patients with Lumbar spinal stenosis and lumbar intervertebral disc degeneration [C] . Z. S. Shima Bahrami, Faezeh Eskandari, Ahmad R. Arshi, International Conference on Knowledge-Based Engineering and Innovation . 2017

机译：腰椎管狭窄合并腰椎间盘退变患者步行步态时空参数的比较研究
5. Biomechanics of the anulus fibrosus and nucleus pulposus of the human lumbar intervertebral disc and the effects of degeneration. [D] . Iatridis, James Christopher. 1996

机译：人腰椎间盘的纤维环和髓核的生物力学及其变性的影响。
6. Decrease with aging of the microcirculatory function of the lumbar vertebral marrow preceding the loss of bone material density and the onset of intervertebral discal degeneration: A study about the potential cause [O] . Lin Ou-yang, Guang-ming Lu 2015

机译：骨材料密度降低和椎间盘退变发作之前腰椎微循环功能的衰老降低：关于潜在原因的研究
7. Decrease with aging of the microcirculatory function of the lumbar vertebral marrow preceding the loss of bone material density and the onset of intervertebral discal degeneration: A study about the potential cause [O] . Ou-yang Lin, Lu Guang-ming 2015

机译：骨质密度降低和椎间盘退变发作前腰椎微循环功能的衰老降低：潜在原因的研究

Effects of alendronate on lumbar intervertebral disc degeneration with bone loss in ovariectomized rats

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