Biological PET-guided adaptive radiotherapy for dose escalation in head and neck cancer: a systematic review

摘要

Current image-guided external beam radiotherapy can be delivered with high spatial accuracy and steep dose gradients. Despite this, the outcome of curative intent (chemo)radiotherapy for head-neck cancer remains subop-timal. After treatment of locally advanced head and neck tumors with (chemo)radiotherapy, loco-regional failure remains a major problem.1 In the search for better treatment outcomes, adaptive radiotherapy has been explored to improve accuracy and allow a more selective dose delivery to tumor while sparing normal tissues.