Retrospective Analysis of Prognostic Factors in 187 Cases of Transformed Mycosis Fungoides

摘要

Transformed mycosis fungoides (MF) can occur in early and late stages of MF and in skin and/or lymph nodes but risk factors associated with transformation of MF are not well known. Screening for large cell transformation (LCT) and CD30 expression might be helpful for prognosis and more aggressive or targeted therapies. In univariate analysis, risk factors associated with disease progression were advanced age, LCT at the time of initial diagnosis of MF, high levels of lactate dehydrogenase, and CD30 expression < 10%.