Children's toxicology from bench to bed - Drug-induced Renal Injury (3): Drug transporters and toxic nephropathy in childhood

摘要

The kidney is susceptible to drugs and environmental substances because of its anatomical and functional reasons, one of which is the existence of drug transport systems in proximal tubular cells. Among those, Organic anion transporter family (OAT family) plays the central role in elimination of drugs from the kidney and development of nephrotoxicity. Regarding drug nephrotoxicity in children, development of the child and the kidney should also be taken into account. This review focuses on the mechanisms of toxic nephropathy in children with special attention to the OAT family.