Relationship Between Amyloid Precursor Protein in Seminal Plasma and Abnormal Penile Sympathetic Skin Response in Lifelong Premature Ejaculation

摘要

Introduction: Hyperactivity of the sympathetic nervous system can play an important role in lifelong premature ejaculation (PE). Our previous study found diat amyloid precursor protein (APP) levels in seminal plasma of patients with PE were clearly increased. Amyloid-beta (Abeta) is derived from APP. Excessive Abeta, especially Abeta42, can cause neuronal dysfunction. Aim: To determine whether APP and Abeta42 are associated with an abnormal penile sympathetic skin response (PSSR). Methods: From November 2015 to April 2016, 24 patients with lifelong PE (mean age = 29.2 ± 5.3) with self-estimated intravaginal ejaculatory latency time no longer than 2 minutes and 10 control subjects (mean age = 28.0 ± 5.5) were enrolled consecutively from andrology clinics. PSSR was measured in patients with lifelong PE. APP and A/542 levels in seminal plasma were determined. Main Outcome Measures: PSSR in patients with lifelong PE and APP and A/342 levels in all subjects.