PTPN11 Mutation is Uncommon in Acute Myeloid Leukemia, but Associated with a Complex Karyotype, Co-mutations in KRAS or NRAS and Poor Prognosis

Ruiz-Cordero R.; Floyd K.; Loghavi S.; Kanagal-Shamanna R.; Yin C. C.; Zuo Z.; Routbort M. J.; Luthra R.; Kantarjian H. M.; Medeiros J. L.; Patel K. P.; Ok C. Y.

首页> 外文期刊>The Journal of molecular diagnostics: JMD >PTPN11 Mutation is Uncommon in Acute Myeloid Leukemia, but Associated with a Complex Karyotype, Co-mutations in KRAS or NRAS and Poor Prognosis

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PTPN11 Mutation is Uncommon in Acute Myeloid Leukemia, but Associated with a Complex Karyotype, Co-mutations in KRAS or NRAS and Poor Prognosis

机译：PTPN11突变在急性髓性白血病中罕见，但与复杂的核型，KRAS或NRA中的共突和预后差相关

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来源
《The Journal of molecular diagnostics: JMD》 |2018年第6期|共2页
作者
Ruiz-Cordero R.; Floyd K.; Loghavi S.; Kanagal-Shamanna R.; Yin C. C.; Zuo Z.; Routbort M. J.; Luthra R.; Kantarjian H. M.; Medeiros J. L.; Patel K. P.; Ok C. Y.;
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Univ Texas MD Anderson Canc Ctr Houston TX 77030 USA;

Univ Texas MD Anderson Canc Ctr Houston TX 77030 USA;

Univ Texas MD Anderson Canc Ctr Houston TX 77030 USA;

Univ Texas MD Anderson Canc Ctr Houston TX 77030 USA;

Univ Texas MD Anderson Canc Ctr Houston TX 77030 USA;

Univ Texas MD Anderson Canc Ctr Houston TX 77030 USA;

Univ Calif San Francisco San Francisco CA 94143 USA;

Univ Calif San Francisco San Francisco CA 94143 USA;

Univ Calif San Francisco San Francisco CA 94143 USA;

Univ Calif San Francisco San Francisco CA 94143 USA;

Univ Calif San Francisco San Francisco CA 94143 USA;

Univ Calif San Francisco San Francisco CA 94143 USA;

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原文格式 PDF
正文语种 eng
中图分类临床医学;
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1. PTPN11 Mutation is Uncommon in Acute Myeloid Leukemia, but Associated with a Complex Karyotype, Co-mutations in KRAS or NRAS and Poor Prognosis [J] . Ruiz-Cordero R., Floyd K., Loghavi S., The Journal of molecular diagnostics: JMD . 2018,第6期

机译：PTPN11突变在急性髓性白血病中罕见，但与复杂的核型，KRAS或NRA中的共突和预后差相关
2. TP53 gene mutation is frequent in patients with acute myeloid leukemia and complex karyotype, and is associated with very poor prognosis [J] . D Bowen, M J Groves, A K Burnett, Leukemia . 2009,第1期

机译：TP53基因突变在急性髓性白血病和复杂的核型患者中经常出现，并且与预后非常差有关
3. Mutations of FLT3, NRAS, KRAS, and PTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia. [J] . Paulsson K, Horvat A, Strombeck B, Genes, Chromosomes and Cancer . 2008,第1期

机译：在高双倍体儿童期急性淋巴细胞白血病中，FLT3，NRAS，KRAS和PTPN11的突变很常见，并且可能相互排斥。
4. A BLSTM with Attention Network for Predicting Acute Myeloid Leukemia Patient’s Prognosis using Comprehensive Clinical Parameters [C] . Chih-Chuan Lu, Jeng-Lin Li, Yu-Fen Wang, . 2019

机译：带有注意力网络的BLSTM，可使用综合的临床参数预测急性髓性白血病患者的预后
5. Pharmacology Profiles of ALK and FLT3 Kinase Inhibitors against Non-Small-Cell Lung Cancer Cells and Acute Myeloid Leukemia Cells with Cancer Driver Mutations [D] . 森政道 2019

机译：ALK和FLT3激酶抑制剂对非小细胞肺癌细胞和急性髓系白血病细胞的癌症驱动突变的药理作用
6. Combined mutations of ASXL1 CBL FLT3 IDH1 IDH2 JAK2 KRAS NPM1 NRAS RUNX1 TET2 and WT1 genes in myelodysplastic syndromes and acute myeloid leukemias [O] . Julien Rocquain, Nadine Carbuccia, Virginie Trouplin, 2010

机译：骨髓增生异常综合症和急性髓细胞性白血病中ASXL1CBLFLT3IDH1IDH2JAK2KRASNPM1NRASRUNX1TET2和WT1基因的组合突变
7. TP53 gene mutation is frequent in patients with acute myeloid leukemia and complex karyotype, and is associated with very poor prognosis [O] . D Bowen, M J Groves, A K Burnett, 2008

机译：TP53基因突变在急性髓性白血病和复杂的核型患者中经常出现，并且与预后非常差有关

PTPN11 Mutation is Uncommon in Acute Myeloid Leukemia, but Associated with a Complex Karyotype, Co-mutations in KRAS or NRAS and Poor Prognosis

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