Effect of different doses of vitamin D supplementation on preterm infants -an updated meta-analysis

摘要

Objective: Vitamin D deficiency (VDD) is common among infants, especially in preterm babies. There are some controversies over its use on body development, immune function and incidence of bronchopulmonary dysplasia (BPD). Methods: We systematically reviewed PubMed, Embase, and Cochrane databases for studies in English, and in Wanfang, VIP, and Cnki databases for Chinese studies (databases were last launched on 1 August 2016). Results: Twelve original random controlled studies (seven in English and five in Chinese) were included (1). There are no differences between high-dose (800-1000 ILJ/d) and low-dose (400IU/d) groups on calcium, phosphorus, and 25(OH)D concentrations (p>.05). However, length gain and head circumference gain are significantly increased in the high-dose group (p<.05) (2). IL-2, Ig-A, and Ig-G levels are significant increased in the vitamin D supplementation group compared with the control group (p<.05) (3). With respect to BPD, there is no significant difference between the vitamin D supplementation group and the control group (p>.05).