Association between serum 25 (OH) vitamin D level at birth and respiratory morbidities among preterm neonates

摘要

Objectives: To determine the association between 25-hydroxyvitamin D [25(OH)D] levels on first day of life with respiratory distress syndrome (RDS), need and duration of mechanical ventilation, and subsequent development of bronchopulmonary dysplasia (BPD) among preterm neonates. Study design: In this case-control study, serum 25(OH)D was measured on first day of life in 65 preterm neonates <34 weeks: 40 with RDS and 25 without RDS and compared between them. Serum 25(OH)D levels were categorized into normal (above 30ng/ml), insufficiency (20-30 ng/ ml), moderate deficiency (10-20 ng/ml), and severe deficiency (<10ng/ml). Neonates with different 25(OH)D levels were compared as regard grade of RDS, initial pH, initial CO_2, need and duration of mechanical ventilation, development of BPD, and mortality.