Multimodal Nutritional Management in Primary Total Knee Arthroplasty: A Randomized Controlled Trial

摘要

Abstract Background This study aims at evaluating the effectiveness of a new multimodal nutritional management (MNM) on albumin (ALB) transfusion, the incidence of electrolyte disorders, blood loss, perioperative levels of ALB and electrolyte, length of hospital stay (LOH), and complications in patients following total knee arthroplasty without tourniquet. Methods A total of 162 patients were randomized to receive either the MNM protocol (n?= 81, experimental group) or traditional protocol (n?= 81, control group). The primary outcomes were the rate and amount of ALB infusion, LOH, total blood loss, maximum hemoglobin drop, allogeneic transfusion rate, and the incidence of electrolyte disorders. The secondary outcomes were levels of ALB and electrolyte at different time points and the incidence of complications. Results The rate and amount of ALB transfusion required in MNM group were significantly lower than those in control group ( P ?= .006, P ?= .021, respectively). LOH was shorter in MNM group ( P P ?= .019, P ?= .028, respectively). Patients in MNM group had higher levels of ALB, sodium, potassium, and calcium than those in control group on the first postoperative day. Conclusion The MNM protocol can effectively low down the amount of ALB transfusion, the number of patients requiring ALB transfusion, the incidence of electrolyte disorders, and LOH following primary total knee arthroplasty without tourniquet. Patients can obtain a smaller decline in ALB, sodium, potassium, and calcium.