In vivo evolution of resistant subpopulations of KPC-producing Klebsiella pneumoniae during ceftazidime/avibactam treatment

Gaibani Paolo; Campoli Caterina; Lewis Russell E.; Volpe Silvia Lidia; Scaltriti Erika; Giannella Maddalena; Pongolini Stefano; Berlingeri Andrea; Cristini Francesco; Bartoletti Michele; Tedeschi Sara; Ambretti Simone

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In vivo evolution of resistant subpopulations of KPC-producing Klebsiella pneumoniae during ceftazidime/avibactam treatment

机译：在CeTtazidime / Avibactam治疗过程中，在CeTtazidime / Avibactam治疗过程中抗KPC生产Klebsiella肺炎的抗性亚群的演变

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Objectives: KPC-producing Klebsiella pneumoniae (KPC-Kp) represent a serious problem worldwide. Herein, we describe the evolution of ceftazidime/avibactam resistance by sequencing longitudinal clinical isolates from a patient with KPC-Kp bloodstream infection undergoing ceftazidime/avibactam treatment.

机译：目的：KPC生产的Klebsiella Pneumoniae（KPC-KP）代表全球的严重问题。在此，我们描述了通过从患有Ceftazidime / Avibactam处理的KPC-KP血流感染患者测序纵向临床分离物的CETTAZIDIME / Avibactam抗性的演变。

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来源
《The Journal of Antimicrobial Chemotherapy》 |2018年第6期|共5页
作者
Gaibani Paolo; Campoli Caterina; Lewis Russell E.; Volpe Silvia Lidia; Scaltriti Erika; Giannella Maddalena; Pongolini Stefano; Berlingeri Andrea; Cristini Francesco; Bartoletti Michele; Tedeschi Sara; Ambretti Simone;
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作者单位

S Orsola Malpighi Univ Hosp Operat Unit Clin Microbiol Bologna Italy;

S Orsola Malpighi Univ Hosp Operat Unit Infect Dis Bologna Italy;

S Orsola Malpighi Univ Hosp Operat Unit Infect Dis Bologna Italy;

S Orsola Malpighi Univ Hosp Operat Unit Clin Microbiol Bologna Italy;

Ist Zooprofilatt Sperimentale Lombardia &

Emilia Risk Anal Unit Parma Italy;

S Orsola Malpighi Univ Hosp Operat Unit Infect Dis Bologna Italy;

Ist Zooprofilatt Sperimentale Lombardia &

Emilia Risk Anal Unit Parma Italy;

S Orsola Malpighi Univ Hosp Operat Unit Clin Microbiol Bologna Italy;

S Orsola Malpighi Univ Hosp Operat Unit Infect Dis Bologna Italy;

S Orsola Malpighi Univ Hosp Operat Unit Infect Dis Bologna Italy;

S Orsola Malpighi Univ Hosp Operat Unit Infect Dis Bologna Italy;

S Orsola Malpighi Univ Hosp Operat Unit Clin Microbiol Bologna Italy;

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正文语种 eng
中图分类治疗学;
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1. In vivo evolution of resistant subpopulations of KPC-producing Klebsiella pneumoniae during ceftazidime/avibactam treatment [J] . Gaibani Paolo, Campoli Caterina, Lewis Russell E., The Journal of Antimicrobial Chemotherapy . 2018,第6期

机译：在CeTtazidime / Avibactam治疗过程中，在CeTtazidime / Avibactam治疗过程中抗KPC生产Klebsiella肺炎的抗性亚群的演变
2. High ceftazidime hydrolysis activity and porin OmpK35 deficiency contribute to the decreased susceptibility to ceftazidime/avibactam in KPC-producing Klebsiella pneumoniae [J] . Shen Zhen, Ding Baixing, Ye Meiping, The Journal of Antimicrobial Chemotherapy . 2017,第7期

机译：高Cittazidime水解活性和Porin OMPK35缺乏促进了在KPC生产的Klebsiella肺炎中对Ceftazidime / Avibactam的易感性降低
3. Use of Ceftazidime-avibactam for the Treatment of Extensively drug-resistant or Pan drug-resistant Klebsiella pneumoniae in Neonates and Children < 5 Years of Age [J] . Elias Iosifidis, Elisavet Chorafa, EleniAgakidou, The Pediatric infectious disease journal . 2019,第8期

机译：使用Ceftazidime-Avibactam用于治疗新生儿和儿童<5岁以下
4. Heat Treatment Effects on Mechanical Properties and Microstructure Evolution of Ferritic Creep Resistant Cr-Mo Steels [C] . M. HAKEM, R. RABAH OTMANI, M. MAZA, International Federation for Heat Treatment and Surface Engineering Congress . 2006

机译：铁素体蠕变抗Cr-Mo钢的机械性能和微观结构演化的热处理效果
5. Antimicrobial treatment of experimental infection due to an extended-spectrum β-lactamase-producing Klebsiella pneumoniae strain [D] . Mathe, Andras 2007

机译：产生大范围β-内酰胺酶的肺炎克雷伯氏菌菌株对实验性感染的抗菌治疗
6. Reduced Ceftazidime-Avibactam Susceptibility in KPC-Producing Klebsiella pneumoniae From Patients Without Ceftazidime-Avibactam Use History – A Multicenter Study in China [O] . Xiaoyan Cui, Bin Shan, Xue Zhang, 2020

机译：从没有头孢他啶 - Avibactam-Avibactam使用历史的患者的患者中减少了Ceftazidime-Avibactam-Avibactam敏感性从患者提供患者 - 中国的多中心研究
7. In vivo evolution of resistant subpopulations of KPC-producing Klebsiella pneumoniae during ceftazidime/avibactam treatment [O] . Paolo Gaibani, Caterina Campoli, Russell E Lewis, 2018

机译：在CeTtakidime / Avibactam治疗过程中，在CeTTazidime / Avibactam治疗过程中抗KPC生产Klebsiella肺炎的抗性群体的体内演变

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In vivo evolution of resistant subpopulations of KPC-producing Klebsiella pneumoniae during ceftazidime/avibactam treatment

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