Genetic polymorphisms of vitamin D metabolism genes and serum level of vitamin D in colorectal cancer

摘要

Background: The metabolism of vitamin D is complex, its receptor (VDR) and proteins encoded by the genes CYP27B2 and CYP24A1 can influence vitamin D serum levels. The aim of this study was to investigate the relationship of the polymorphisms of VDR (ApaI and BsmI), CYP27B1 and CYP24A1 with serum vitamin D levels in both forms, 25(OH)D-3 (circulating form) and 1,25(OH)(2)D-3 (active form), in colorectal cancer (CRC) patients.