Edaravone attenuates neuronal apoptosis in hypoxic-ischemic brain damage rat model via suppression of TRAIL signaling pathway

Li Chunyi; Mo Zhihuai; Lei Junjie; Li Huiqing; Fu Ruying; Huang Yanxia; Luo Shijian; Zhang Lei

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Edaravone attenuates neuronal apoptosis in hypoxic-ischemic brain damage rat model via suppression of TRAIL signaling pathway

机译：埃达拉夫酮通过抑制TRAIL信号通路抑制缺氧缺血性脑损伤大鼠模型中的神经元细胞凋亡

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Background and objectives: Edaravone is a new type of oxygen free radical scavenger and able to attenuate various brain damage including hypoxic-ischemic brain damage (HIBD). This study was aimed at investigating the neuroprotective mechanism of edaravone in rat hypoxic-ischemic brain damage model and its correlation with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) signaling pathway.

机译：背景和目标：埃德拉押是一种新型的氧自由基清除剂，能够衰减各种脑损伤，包括缺氧缺血性脑损伤（HIBD）。本研究旨在研究依达拉夫松在大鼠缺氧缺血性脑损伤模型中的神经保护机制及其与肿瘤坏死因子相关凋亡诱导配体（TRAIL）信号通路的相关性。

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《The international journal of biochemistry and cell biology》 |2018年第2018期|共9页
作者
Li Chunyi; Mo Zhihuai; Lei Junjie; Li Huiqing; Fu Ruying; Huang Yanxia; Luo Shijian; Zhang Lei;
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作者单位

Sun Yat Sen Univ Affiliated Hosp 5 Dept Neurol 52 Meihua East Rd Zhuhai 519000 Guangdong;

Sun Yat Sen Univ Affiliated Hosp 5 Dept Neurol 52 Meihua East Rd Zhuhai 519000 Guangdong;

Sun Yat Sen Univ Affiliated Hosp 5 Dept Neurol 52 Meihua East Rd Zhuhai 519000 Guangdong;

Sun Yat Sen Univ Affiliated Hosp 5 Dept Neurol 52 Meihua East Rd Zhuhai 519000 Guangdong;

Sun Yat Sen Univ Affiliated Hosp 5 Dept Neurol 52 Meihua East Rd Zhuhai 519000 Guangdong;

Sun Yat Sen Univ Affiliated Hosp 5 Dept Neurol 52 Meihua East Rd Zhuhai 519000 Guangdong;

Sun Yat Sen Univ Affiliated Hosp 5 Dept Neurol 52 Meihua East Rd Zhuhai 519000 Guangdong;

Sun Yat Sen Univ Affiliated Hosp 5 Dept Neurol 52 Meihua East Rd Zhuhai 519000 Guangdong;

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原文格式 PDF
正文语种 eng
中图分类生物化学;
关键词
Edaravone; TRAIL; Brain damage; Neuronal apoptosis; Caspase-3;

机译：埃德拉武龙;小径;脑损伤;神经元细胞凋亡;Caspase-3;

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专利

1. Edaravone attenuates neuronal apoptosis in hypoxic-ischemic brain damage rat model via suppression of TRAIL signaling pathway [J] . Li Chunyi, Mo Zhihuai, Lei Junjie, The international journal of biochemistry and cell biology . 2018,第期

机译：埃达拉夫酮通过抑制TRAIL信号通路抑制缺氧缺血性脑损伤大鼠模型中的神经元细胞凋亡
2. Quercetin attenuates neuronal autophagy and apoptosis in rat traumatic brain injury model via activation of PI3K/Akt signaling pathway [J] . Du Guoliang, Zhao Zongmao, Chen Yonghan, Neurological Research: An Interdisciplinary Quarterly Journal . 2016,第11期

机译：槲皮素通过激活PI3K / Akt信号通路减轻大鼠脑损伤模型的神经元自噬和凋亡
3. Intranasal Administration of Interferon Beta Attenuates Neuronal Apoptosis via the JAK1/STAT3/BCL-2 Pathway in a Rat Model of Neonatal Hypoxic-Ischemic Encephalopathy [J] . Di Chen, Jerry Flores, Brandon J. Dixon, Asn Neuro . 2016,第5期

机译：鼻内注射干扰素β通过JAK1 / STAT3 / BCL-2途径减轻新生鼠缺氧缺血性脑病模型的神经元凋亡
4. Markers of neuronal and glial cells damage in perinatal hypoxic-ischemic brain injury [C] . Okuneva O., Taranushenko T., Salmina A., World Asthma and COPD Forum . 2010

机译：神经元和神经胶质细胞的标记在围产期缺氧缺血性脑损伤中的损伤
5. The study of signaling pathways controlling neuronal apoptosis inhibitory protein (NAIP) expression and function. [D] . Coffill, Cynthia Rose. 2006

机译：控制神经元凋亡抑制蛋白（NAIP）表达和功能的信号通路的研究。
6. Edaravone attenuates neuronal apoptosis in hippocampus of rat traumatic brain injury model via activation of BDNF/TrkB signaling pathway [O] . Yuexia Ding, Wei Zhu, Wei Kong, 2021

机译：埃达拉夫酮通过激活BDNF / TRKB信号通路的激活衰减大鼠创伤性脑损伤模型的神经元细胞凋亡
7. Edaravone attenuates neuronal apoptosis in hippocampus of rat traumatic brain injury model via activation of BDNF/TrkB signaling pathway [O] . Yuexia Ding, Wei Zhu, Wei Kong, 2021

机译：埃达拉夫酮通过激活BDNF / TRKB信号通路的激活衰减大鼠创伤性脑损伤模型的神经元细胞凋亡

Edaravone attenuates neuronal apoptosis in hypoxic-ischemic brain damage rat model via suppression of TRAIL signaling pathway

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