LAYER-SPECIFIC STRAIN RESPONSE FOLLOWING ACUTE PRESSURE UNLOADING IN SEVERE AORTIC STENOSIS

摘要

BACKGROUND: The left ventricular (LV) wall is composed of endocardial, mid-myocardial, and epicardial layer and each myocardial layer have different vulnerability to ischemia and pressure overload. However, the effects of pressure unloading after transcatheter aortic valve replacement (TAVR) or aortic valve replacement (AVR) on the mechanics of three myocardial layers are largely unknown in patient with severe aortic stenosis (AS). The present study evaluated change in LV biomechanics, layer-by-layer, following acute pressure unloading in patients with severe AS.