ACTIVATED PLATELETS PROMOTE THE PROGRESSION OF CALCIFIC AORTIC VALVE STENOSIS

摘要

BACKGROUND: Calcific aortic valve stenosis (CAVS) is a chronic disorder characterized by ectopic mineralization. Studies have shown that circulating platelets are activated during CAVS. However, whether platelets are actively involved into the pathobiology of CAVS is presently unknown. We have recently showed that autotaxin (ATX), which is secreted by valve interstitial cells (VICs), promotes the production of lysophosphatidic acid (LPA) with pro-osteogenic activity. We hypothesized that platelets could interact with ATX and promote the production of LPA and the osteogenic transition of VICs.